Chloroquine-d₄ phosphate (Synonyms: 磷酸氯喹 d₄ (磷酸盐))

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Chloroquine-d₄ (phosphate) 是 Chloroquine phosphate 的氘代物。Chloroquine phosphate 是一种广泛用于疟疾和类风湿性关节炎的抗疟疾和抗炎剂。Chloroquine phosphate 是 autophagy 和 toll-like receptors (TLRs) 的抑制剂。Chloroquine phosphate 有效抑制 SARS-CoV-2 (COVID-19) 感染 (E

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Chloroquine-d₄ phosphate Chemical Structure

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Chloroquine phosphate In-stock

Chloroquine In-stock

Chloroquine-d₅ In-stock

Chloroquine dihydrochloride In-stock

Chloroquine phosphate (Standard) In-stock

Chloroquine-d₅ diphosphate 询价

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Chloroquine-d₄ phosphate 相关抗体

Chloroquine-d₄ phosphate 相关产品

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参考文献

生物活性

Chloroquine-d₄ (phosphate) is the deuterium labeled Chloroquine phosphate. Chloroquine phosphate is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. Chloroquine phosphate is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine phosphate is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro (EC50=1.13 μM)[1][2][3][4].

IC₅₀ & Target

Plasmodium

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Chloroquine-d₄ phosphate 相关抗体:

分子量

519.89

Formula
C₁₈H₂₈D₄ClN₃O₈P₂

非标记 CAS
50-63-5

中文名称
磷酸氯喹 d₄ (磷酸盐)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

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Data Sheet (525 KB) 产品使用指南 (1538 KB)

参考文献

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Said A, et al. Chloroquine promotes IL-17 production by CD4+ T cells via p38-dependent IL-23 release by monocyte-derived Langerhans-like cells. J Immunol. 2014 Dec 15;193(12):6135-43. [Content Brief]

[3]. Tuomela J, et al. Chloroquine has tumor-inhibitory and tumor-promoting effects in triple-negative breast cancer. Oncol Lett. 2013 Dec;6(6):1665-1672. [Content Brief]

[4]. Mohamed FE, et al. Effect of toll-like receptor 7 and 9 targeted therapy to prevent the development of hepatocellular carcinoma. Liver Int. 2014 Jul 2. doi: 10.1111/liv.12626. [Content Brief]

[5]. Wang M, et al. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res. 2020 Mar;30(3):269-271. [Content Brief]

[6]. Colson P, et al. Chloroquine and hydroxychloroquine as available weapons to fight COVID-19. Int J Antimicrob Agents. 2020;55(4):105932. [Content Brief]

[7]. Savarino A, et al. The anti-HIV-1 activity of chloroquine. J Clin Virol. 2001;20(3):131-135. [Content Brief]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Said A, et al. Chloroquine promotes IL-17 production by CD4+ T cells via p38-dependent IL-23 release by monocyte-derived Langerhans-like cells. J Immunol. 2014 Dec 15;193(12):6135-43.

[3]. Tuomela J, et al. Chloroquine has tumor-inhibitory and tumor-promoting effects in triple-negative breast cancer. Oncol Lett. 2013 Dec;6(6):1665-1672.

[4]. Mohamed FE, et al. Effect of toll-like receptor 7 and 9 targeted therapy to prevent the development of hepatocellular carcinoma. Liver Int. 2014 Jul 2. doi: 10.1111/liv.12626.

[5]. Wang M, et al. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res. 2020 Mar;30(3):269-271.

[6]. Colson P, et al. Chloroquine and hydroxychloroquine as available weapons to fight COVID-19. Int J Antimicrob Agents. 2020;55(4):105932.

[7]. Savarino A, et al. The anti-HIV-1 activity of chloroquine. J Clin Virol. 2001;20(3):131-135.

Chloroquine-d₄ phosphate 相关分类

同位素标记物

科研领域用同位素标记物临床质谱同位素内标品同位素标记抑制剂氘（²H， D）

同位素标记抑制剂体内实验中应用较多的稳定同位素标记抑制剂药物浓度检测

Inflammation/Immunology Infection Cancer

肿瘤靶向治疗肿瘤靶向治疗肿瘤免疫肿瘤免疫肿瘤代谢与转移肿瘤代谢与转移

Others Autophagy Immunology/Inflammation Anti-infection

Isotope-Labeled Compounds Parasite Autophagy SARS-CoV Toll-like Receptor (TLR) HIV Antibiotic

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Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start) × 体积 _(start) = 浓度 _(final) × 体积 _(final)

× = ×

C1 V1 C2 V2

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Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Keywords:

Chloroquine-d₄磷酸氯喹 d₄ (磷酸盐)Isotope-Labeled CompoundsParasiteAutophagySARS-CoVToll-like Receptor (TLR)HIVAntibioticSARS coronavirusHuman immunodeficiency virusInhibitorinhibitorinhibit

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Chloroquine-d₄ phosphate (Synonyms: 磷酸氯喹 d₄ (磷酸盐))

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Chloroquine-d4 phosphate (Synonyms: 磷酸氯喹 d4 (磷酸盐))

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Chloroquine-d₄ phosphate (Synonyms: 磷酸氯喹 d₄ (磷酸盐))

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Chloroquine-d₄ phosphate 相关抗体

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