2. Academic Validation
  3. Antiplasmodial and antitrypanosomal activity of bicyclic amides and esters of dialkylamino acids

Antiplasmodial and antitrypanosomal activity of bicyclic amides and esters of dialkylamino acids

  • Bioorg Med Chem. 2009 May 15;17(10):3595-603. doi: 10.1016/j.bmc.2009.04.002.
Johanna Faist 1,  Werner Seebacher,  Christian Schlapper,  Marcel Kaiser,  Reto Brun,  Robert Saf,  Robert Weis
Affiliations

Affiliation

  • 1 Institute of Pharmaceutical Sciences, Pharmaceutical Chemistry, University of Graz, Universitätsplatz 1, A-8010 Graz, Austria.
PMID: 19395265 DOI: 10.1016/j.bmc.2009.04.002
Abstract

Several bicyclic amides and esters of dialkylamino acids were prepared. Their activities against a multiresistant strain of Plasmodium falciparum and against Trypanosoma brucei rhodesiense (STIB 900) were examined. Structure-activity relationships were discussed. Particularly the ester compounds showed good antiplasmodial and antitrypanosomal activity and a single compound was tested in vivo against Plasmodium berghei.

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