2. 一站式药筛
  3. 化合物库
  4. 生物活性化合物库系列
  5. 疾病相关化合物库
  6. 疼痛相关化合物库
疼痛相关化合物库 - Pain-Related Compound Library

Cat. No.: HY-L139

疼痛是一种由组织损伤刺激引起的痛苦感知。根据国际疼痛研究协会（IASP）的定义，疼痛指“与实际或潜在组织损伤相关的，或用于描述此类损伤的不愉快的感觉和情绪体验”。

疼痛通常根据其位置、持续时间、潜在原因和强度等进行分类。分类包括急性和慢性疼痛、肌肉疼痛和神经疼痛等。疼痛是大多数疾病的主要症状，严重影响患者的生活质量和机体功能。在疼痛的药物治疗中，传统上通常使用抗炎药和阿片类镇痛剂，但副作用较大。近年来，靶向ERK/MAPK通路等靶点的靶向药物逐渐成为研究热点。

MCE可以提供2,082种靶向疼痛关键靶点的化合物，是进行疼痛相关研究及抗疼痛药物开发的有用工具。

我们将在明确您的产品用途后，向符合资质的客户通过定制合成服务的方式提供 MCE 疼痛相关化合物库，我们为该库中的所有产品提供溶液包装或粉末包装。溶液包装中，2,046 个产品以 10 mM 浓度提供，28 个产品以 2 mM 浓度提供，8 个产品以 3 mg/mL 浓度提供。

溶液包装中，我们对于溶液状态稳定且溶解度不低于 10 mM 的产品，提供 10 mM 溶液；对于溶液状态稳定且溶解度介于 2~10 mM 的产品，我们提供 2 mM 溶液；对于溶液状态稳定、分子量不确定且溶解度不低于 3 mg/mL产品，我们提供 3 mg/mL 溶液。

  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack
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Compound Screening Libraries

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MCE 顾客使用化合物库产品发表的文献

  • 生物活性
  • 产品详情
  • 化合物库组成

活性描述 & 特点

Biological Activity

•    A unique collection of 2,082 Pain-related compounds for high throughput screening (HTS) and high content screening (HCS).

•    A useful tool for new anti-pain drugs discovery.

•   Target diverse, medicinally active and cell permeable.

•   Bioactivity and safety confirmed by preclinical research and clinical trials.

•   More detailed compound information with structure, IC50, and other chemical & biological data.

•   High purity and quality validated by NMR and LC/MS.

产品详情

Product Details

Formulation:

A collection of 2,082 pain related compounds supplied as pre-dissolved Solutions or Solid
Solution: 2,046 compounds supplied in 10 mM solution, 28 compounds supplied in 2 mM solution, 8 compounds supplied in 3 mg/mL solution.

Layout:

96-well storage tube or 96-well plate: 1st and 12th column are left empty.
384-well plate: the first two columns and the last two columns are left empty.
Compounds with different concentrations or dissolved in different solvents will be put on separate plates. This way of layout may increase the number of plates because there could be three solvents and three concentrations.
If you have other requirements, please let us know.

Container:

96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode

Storage:

-80°C

Shipping:

Blue ice

化合物库组成

Composition

NF-κB (278)

PI3K (205)

Akt (143)

ERK (108)

MMP (108)

mTOR (108)

Src (80)

AMPK (78)

JAK (77)

JNK (51)

MEK (49)

COX (40)

STAT (37)

FAAH (29)

iGluR (28)

PKA (27)

EGFR (22)

HIV (22)

VEGFR (20)

CDK (18)

FLT3 (18)

FGFR (15)

PDGFR (15)

PPAR (14)

PARP (12)

PKC (12)

FAK (11)

Raf (9)

HDAC (8)

HSV (8)

IKK (8)

ROCK (8)

Wnt (8)

HCV (7)

PTEN (7)

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  •  特定化合物
  •  化合物数量
  •  产品排布图
  •  浓度
  •  形式（固体或溶液）
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联系专家定制
  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack
  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack

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    产品名称：
    Pain-Related Compound Library
    目录号：
    HY-L139
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