2. Academic Validation
  3. HJURP regulates cell proliferation and chemo-resistance via YAP1/NDRG1 transcriptional axis in triple-negative breast cancer

HJURP regulates cell proliferation and chemo-resistance via YAP1/NDRG1 transcriptional axis in triple-negative breast cancer

  • Cell Death Dis. 2022 Apr 22;13(4):396. doi: 10.1038/s41419-022-04833-6.
Misha Mao  # 1 2,  Yunlu Jia  # 3,  Yongxia Chen 1 2,  Jingjing Yang 1 2,  Ling Xu 1 2,  Xun Zhang 1 2,  Jichun Zhou 1 2,  Zhaoqing Li 1 2,  Cong Chen 1 2,  Siwei Ju 1 2,  Linbo Wang 4 5
Affiliations

Affiliations

  • 1 Department of Surgical Oncology, Affiliated Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, 310000, Zhejiang, China.
  • 2 Biomedical Research Center and Key Laboratory of Biotherapy of Zhejiang Province, Hangzhou, 310000, Zhejiang, China.
  • 3 Department of Medical Oncology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, Zhejiang, China.
  • 4 Department of Surgical Oncology, Affiliated Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, 310000, Zhejiang, China. linbowang@zju.edu.cn.
  • 5 Biomedical Research Center and Key Laboratory of Biotherapy of Zhejiang Province, Hangzhou, 310000, Zhejiang, China. linbowang@zju.edu.cn.
  • # Contributed equally.
PMID: 35459269 DOI: 10.1038/s41419-022-04833-6
Abstract

Triple-negative breast Cancer is still a difficult point in clinical treatment at present, and a deep study of its pathogenesis has great clinical value. Therefore, our research mainly focuses on exploring the progression of triple-negative breast Cancer and determines the important role of the HJURP/YAP1/NDRG1 transcriptional regulation axis in triple-negative breast Cancer. We observed significantly increased HJURP expression levels in triple-negative breast Cancer compared to other subtypes. HJURP could affect the level of ubiquitination modification of YAP1 protein and then regulate its downstream transcriptional activity. Mechanistically, we found that YAP1 positively regulates NDRG1 transcription by binding the promoter region of the NDRG1 gene. And HJURP/YAP1/NDRG1 axis could affect cell proliferation and chemotherapy sensitivity in triple-negative breast Cancer. Taken together, these findings provide insights into the transcriptional regulation axis of HJURP/YAP1/NDRG1 in triple-negative breast Cancer progression and therapeutic response.

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