2. Academic Validation
  3. Parallel synthesis and anti-malarial activity of a sulfonamide library

Parallel synthesis and anti-malarial activity of a sulfonamide library

  • Bioorg Med Chem Lett. 2002 Sep 16;12(18):2595-8. doi: 10.1016/s0960-894x(02)00475-4.
A Ryckebusch 1,  R Déprez-Poulain,  M A Debreu-Fontaine,  R Vandaele,  E Mouray,  P Grellier,  C Sergheraert
Affiliations

Affiliation

  • 1 Institut de Biologie et Institut Pasteur de Lille, UMR CNRS 8525, Université de Lille II, 1 rue du Professeur Calmette, B.P. 447, 59021, Lille, France.
PMID: 12182868 DOI: 10.1016/s0960-894x(02)00475-4
Abstract

Solution-phase synthesis and evaluation of a library of 31 sulfonamides as inhibitors of a chloroquine-resistant strain of Plasmodium falciparum are described. The most potent compound displayed an activity 100-fold better than chloroquine. Experiments using a fluorescent sulfonamide derivative suggest that their site of action inside the Parasite is different to that of chloroquine.

Figures
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z