2. 一站式药筛
  3. 化合物库
  4. 生物活性化合物库系列
  5. 已知活性化合物库
  6. 多靶点化合物库
多靶点化合物库 - Multi-Target Compound Library

Cat. No.: HY-L176

疾病的发生往往与多个靶点和通路相关联，且疾病形成的因素复杂多样，因此需要开发功能更强大的药物。据统计，在 2015-2017 期间 FDA 批准上市的药物中有 21% 的药物是多靶点化合物。多靶点化合物是指一个药物靶向多个与疾病相关的靶点或某个靶点的多个亚型，多靶点化合物可以应用到药物筛选或定向配体设计中，因为这种化合物的靶标多样且明确，所以在新药研发开展机制研究的过程中具有节约时间、药物成本等特点。此外，由于药物靶点多样化，可以将多种策略应用到药理学研究。

MCE 可以提供 4,561 种多靶点化合物，靶向两个及以上的不同靶点或同一靶点的不同亚型，可以用于靶蛋白配体筛选或药物开发。

我们将在明确您的产品用途后，向符合资质的客户通过定制合成服务的方式提供 MCE 多靶点化合物库，我们为该库中的所有产品提供溶液包装或粉末包装。溶液包装中，4,467 个产品以 10 mM 浓度提供，84 个产品以 2 mM 浓度提供，10 个产品以 3 mg/mL 浓度提供。

溶液包装中，我们对于溶液状态稳定且溶解度不低于 10 mM 的产品，提供 10 mM 溶液；对于溶液状态稳定且溶解度介于 2~10 mM 的产品，我们提供 2 mM 溶液；对于溶液状态稳定、分子量不确定且溶解度不低于 3 mg/mL产品，我们提供 3 mg/mL 溶液。

  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack
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Compound Screening Libraries

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MCE 顾客使用化合物库产品发表的文献

  • 生物活性
  • 产品详情
  • 化合物库组成

活性描述 & 特点

Biological Activity

•   Bioactivity and safety confirmed by preclinical research and clinical trials. Some have been approved by FDA.

•   Widely used in the research focus areas such as Cancer, Stem Cell, Neuronal Signaling, Immunity, and more.

•   Structurally diverse, medicinally active, and cell permeable.

•   More detailed compound information with structure, IC50, and other chemical & biological data.

•   NMR and HPLC validated to ensure high purity and quality.

•   All compounds are in stock and continuously updated.

产品详情

Product Details

Formulation:

A collection of 4,561 multi-target compounds supplied as pre-dissolved Solutions or Solid.
Solution: 4,467 compounds supplied in 10 mM solution, 84 compounds supplied in 2 mM solution, 10 compounds supplied in 3 mg/mL solution.

Layout:

96-well storage tube or 96-well plate: 1st and 12th column are left empty.
384-well plate: the first two columns and the last two columns are left empty.
Compounds with different concentrations or dissolved in different solvents will be put on separate plates. This way of layout may increase the number of plates because there could be three solvents and three concentrations.
If you have other requirements, please let us know.

Container:

96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode

Storage:

-80°C

Shipping:

Blue ice or dry ice

化合物库组成

Composition

NF-κB (194)

CDK (179)

HIV (169)

PI3K (165)

COX (144)

EGFR (128)

VEGFR (125)

Akt (122)

Fungal (103)

mTOR (93)

ERK (92)

HDAC (92)

JAK (91)

PDGFR (80)

PARP (75)

FGFR (71)

PPAR (71)

MMP (68)

STAT (68)

FLT3 (65)

mAChR (61)

PKC (59)

HSV (57)

c-Kit (54)

Wnt (54)

GSK-3 (52)

Src (50)

HCV (48)

mGluR (45)

ROCK (44)

JNK (42)

AMPK (41)

iGluR (40)

Raf (39)

HBV (35)

HSP (34)

MEK (34)

IKK (30)

相关服务推荐
定制您专属的化合物库
  •  特定化合物
  •  化合物数量
  •  产品排布图
  •  浓度
  •  形式（固体或溶液）
  •  YES
联系专家定制
  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack
  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack

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    产品名称：
    Multi-Target Compound Library
    目录号：
    HY-L176
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