2. 一站式药筛
  3. 化合物库
  4. 生物活性化合物库系列
  5. 根据产品特点分类
  6. 细胞死亡化合物库
细胞死亡化合物库 - Cell Death Library

Cat. No.: HY-L162

细胞死亡在身体的发育和维持体内平衡以防止疾病的发展中起着关键作用。 根据所涉及过程的调节，细胞死亡可以定义为程序性死亡和非程序性死亡。程序性细胞死亡 (PCD) 可分为裂解性细胞死亡和非裂解性细胞死亡，主要包括凋亡、坏死性凋亡和细胞焦亡。非程序性细胞死亡 (Non-PCD) 一般指坏死。与意外细胞死亡 (ACD) 形成鲜明对比的是，调节性细胞死亡 (RCD) 依赖于专用的分子机制。细胞死亡包括内在细胞凋亡、外在细胞凋亡、坏死性凋亡、铁死亡、细胞焦亡、溶酶体依赖性细胞死亡等。

MCE 收录了 2,578 种细胞死亡相关化合物，涵盖多个靶点，如凋亡、铁死亡、焦亡、坏死性凋亡等，是筛选细胞死亡药物的有用工具。

我们将在明确您的产品用途后，向符合资质的客户通过定制合成服务的方式提供 MCE 细胞死亡化合物库，我们为该库中的所有产品提供溶液包装或粉末包装。溶液包装中，2,520 个产品以 10 mM 浓度提供，50 个产品以 2 mM 浓度提供，8 个产品以 3 mg/mL 浓度提供。

溶液包装中，我们对于溶液状态稳定且溶解度不低于 10 mM 的产品，提供 10 mM 溶液；对于溶液状态稳定且溶解度介于 2~10 mM 的产品，我们提供 2 mM 溶液；对于溶液状态稳定、分子量不确定且溶解度不低于 3 mg/mL产品，我们提供 3 mg/mL 溶液。

  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack
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Compound Screening Libraries

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MCE 顾客使用化合物库产品发表的文献

  • 生物活性
  • 产品详情
  • 化合物库组成

活性描述 & 特点

Biological Activity

•   A unique collection of 2,578 cell death compounds for high throughput screening (HTS) and high content screening (HCS).

•   Targets such as Apoptosis, Ferroptosis, Pyroptosis, and more.

•   A useful tool for drug discovery.

•   Target diverse, medicinally active and cell permeable.

•   Bioactivity and safety confirmed by preclinical research and clinical trials. Some have been approved by FDA.

•   More detailed compound information with structure, IC50, and other chemical & biological data.

•   High purity and quality validated by NMR and LC/MS.

产品详情

Product Details

Formulation:

A collection of 2,578 cell death compounds supplied as pre-dissolved Solutions or Solid
Solution: 2,520 compounds supplied in 10 mM solution, 50 compounds supplied in 2 mM solution, 8 compounds supplied in 3 mg/mL solution.

Layout:

96-well storage tube or 96-well plate: 1st and 12th column are left empty.
384-well plate: the first two columns and the last two columns are left empty.
Compounds with different concentrations or dissolved in different solvents will be put on separate plates. This way of layout may increase the number of plates because there could be three solvents and three concentrations.
If you have other requirements, please let us know.

Container:

96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode

Storage:

-80°C

Shipping:

Blue ice or dry ice

化合物库组成

Composition

PI3K (73)

Akt (59)

mTOR (51)

CDK (48)

HIV (46)

COX (45)

HDAC (45)

EGFR (40)

STAT (39)

VEGFR (38)

PARP (32)

FLT3 (31)

PDGFR (31)

JAK (30)

HSP (26)

Src (26)

ERK (25)

AMPK (24)

c-Kit (23)

PKC (22)

Ras (21)

Wnt (21)

FGFR (20)

HSV (20)

MMP (20)

PPAR (19)

MEK (18)

FXR (17)

Raf (17)

JNK (16)

FAAH (15)

CFTR (14)

FAK (14)

GSK-3 (13)

IAP (13)

c-Myc (12)

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  •  特定化合物
  •  化合物数量
  •  产品排布图
  •  浓度
  •  形式（固体或溶液）
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联系专家定制
  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack
  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack

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    产品名称：
    Cell Death Library
    目录号：
    HY-L162
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