2. Academic Validation
  3. Synthesis and biological evaluation of new heterocyclic quinolinones as anti-parasite and anti-HIV drug candidates

Synthesis and biological evaluation of new heterocyclic quinolinones as anti-parasite and anti-HIV drug candidates

  • Bioorg Med Chem Lett. 2009 Oct 15;19(20):5962-4. doi: 10.1016/j.bmcl.2009.08.013.
Albert Darque 1,  Aurélien Dumètre,  Sébastien Hutter,  Gilles Casano,  Maxime Robin,  Christophe Pannecouque,  Nadine Azas
Affiliations

Affiliation

  • 1 UMR-MD3-Relations Hôte-Parasites, Pharmacologie et Thérapeutique, Faculté de Pharmacie, Université de la Méditerranée, Marseille Cedex 05, France.
PMID: 19748781 DOI: 10.1016/j.bmcl.2009.08.013
Abstract

We have synthesized quinolinones with potential antiparasitic and anti-HIV activities by an original two-step method involving microwave irradiation and have evaluated their activities against Plasmodium falciparum, Leishmania donovani, Trichomonas vaginalis, and HIV. None of the tested compounds had been previously described using this method of synthesis. One of the compounds had interesting antiparasitic and anti-HIV activity, which could be improved by substitution with different radicals.

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