2. Immunology/Inflammation Apoptosis
  3. NO Synthase COX Interleukin Related TNF Receptor
  4. Shizukaol B

Shizukaol B 是一种椴树烷型二聚倍半萜类化合物，曾从青牡丹 (Chloranthus henryi) 全株中分离得到。Shizukaol B 对脂多糖 (LPS) 诱导的 BV2 微胶质细胞活化具有抗炎作用。Shizukaol B 抑制诱导型一氧化氮合酶 (iNOS) 和 COX-2，还抑制 NO 产生，和 TNF-α、IL-1β 表达。

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Shizukaol B Chemical Structure

Shizukaol B Chemical Structure

CAS No. : 142279-40-1

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规格 价格 是否有货 数量
1 mg ￥4130
1 - 2 周
5 mg   询价  
10 mg   询价  

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Shizukaol B 相关抗体

Top Publications Citing Use of Products

查看 NO Synthase 亚型特异性产品:

查看所有亚型
nNOS iNOS eNOS

查看 COX 亚型特异性产品:

查看所有亚型
COX COX-1 COX-2 COX-3

查看 Interleukin Related 亚型特异性产品:

查看所有亚型
IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

查看 TNF Receptor 亚型特异性产品:

查看所有亚型
TNFRSF1A/CD120a TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF7/CD27 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Shizukaol B is a lindenane-type dimeric sesquiterpene, used to be isolated from the whole plant of Chloranthus henryi. Shizukaol B has anti-inflammatory effect against lipopolysaccharide (LPS)-induced activation of BV2 microglial cells. Shizukaol B inhibits iNOS and COX-2, and suppresses NO production, TNF-α, and IL-1β expression[1].

IC50 & Target[1]

COX-2

 

iNOS

 

IL-1β

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
C8166 CC50
0.02 μM
Compound: 8
Cytotoxicity against human C8166 cells by MTT assay
Cytotoxicity against human C8166 cells by MTT assay
[PMID: 21650224]
RAW264.7 IC50
> 50 μM
Compound: 4
Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production preincubated for 30 mins followed by LPS stimulation and measured after 24 hrs by Griess reagent based colorimetric method
Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production preincubated for 30 mins followed by LPS stimulation and measured after 24 hrs by Griess reagent based colorimetric method
[PMID: 30724564]
RAW264.7 IC50
0.15 μM
Compound: shizukaol B
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated nitric oxide production pretreated for 2 hrs before LPS challenge measured after 18 hrs by Griess method
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated nitric oxide production pretreated for 2 hrs before LPS challenge measured after 18 hrs by Griess method
[PMID: 22372956]
RAW264.7 IC50
14.79 μM
Compound: 11
Inhibition of LPS-induced NO production in mouse RAW264.7 cells after 24 hrs by Griess assay
Inhibition of LPS-induced NO production in mouse RAW264.7 cells after 24 hrs by Griess assay
[PMID: 27177824]
WI-38 IC50
16.7 μM
Compound: 30
Cytotoxicity against human WI38 cells after 72 hrs by CCK8 assay
Cytotoxicity against human WI38 cells after 72 hrs by CCK8 assay
[PMID: 27997206]
体外研究
(In Vitro)

Shizukaol B (25 μM; 0-60 min) 抑制 LPS (1 μg/mL; 0-60 min) 介导的 c-Jun N 末端激酶 1/2 (JNK) 激活，不影响 ERK1/2 或 p38 磷酸化[1]。
Shizukaol B (12.5-50 μM; 4 h) 抑制 LPS 诱导 (1 μg/mL; 24 h) 的 NO 生成，抑制 iNOS 和 COX-2 的表达[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Shizukaol B 相关抗体:
分子量

732.77

Formula

C40H44O13
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Shizukaol B 相关分类

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  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Shizukaol B142279-40-1NO SynthaseCOXInterleukin RelatedTNF ReceptorNitric oxide synthasesNOSCyclooxygenaseILTumor Necrosis Factor ReceptorTNFRInhibitorinhibitorinhibit

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