2. Academic Validation
  3. Chloraserrtone A, a Sesquiterpenoid Dimer from Chloranthus serratus

Chloraserrtone A, a Sesquiterpenoid Dimer from Chloranthus serratus

  • J Nat Prod. 2019 Feb 22;82(2):407-411. doi: 10.1021/acs.jnatprod.8b00418.
Bai Bai 1,  Shao-Xia Ye 1,  De-Po Yang 1 2,  Long-Ping Zhu 1 2,  Gui-Hua Tang 1 2,  Yun-Yun Chen 1,  George Qian Li 3,  Zhi-Min Zhao 1 2
Affiliations

Affiliations

  • 1 School of Pharmaceutical Sciences , Sun Yat-sen University , Guangzhou , Guangdong 510006 , People's Republic of China.
  • 2 Guangdong Technology Research Center for Advanced Chinese Medicine , Guangzhou , Guangdong 510006 , People's Republic of China.
  • 3 Centre for Complementary Medicine Research , University of Western Sydney , Sydney , NSW 1797 Australia.
PMID: 30724564 DOI: 10.1021/acs.jnatprod.8b00418
Abstract

Chloraserrtone A (1), a new sesquiterpenoid dimer with two lindenane-type sesquiterpenoid monomers bridged by two six-membered rings, was obtained from Chloranthus serratus. A combination of UV, IR, NMR, HRESIMS, and X-ray diffraction data were used to elucidate the structure of 1. Compound 1 represents the first lindenane-type sesquiterpenoid dimer with extremely unique C-15-C-15', C-4-C-6', and C-6-C-11' linkages to form two six-membered rings between the monomeric units. A plausible biosynthesis toward chloraserrtone A is proposed. This new compound (1), together with the known lindenane dimers (2-11), were assessed for their inhibitory effects on lipopolysaccharide-induced NO production in RAW264.7 cells. Compound 6 showed activity with an IC50 value of 3.7 μM.

Figures
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z