2. Immunology/Inflammation
  3. COX
  4. LM-4108

LM-4108  (Synonyms: N-(2-Phenylethyl)-indomethacin amide)

目录号: HY-123639
产品使用指南

摩尔计算器

LM-4108 (N-(2-Phenylethyl)-indomethacin amide) 是一种选择性和具有口服活性的 COX-2 抑制剂，对纯化的人 COX-2 的 IC50 为 0.06 μM。LM-4108 具有抗炎活性，可能对预防癌症有效。10 μM LM-4108 在大鼠、人和小鼠肝微粒体中的消失半衰期分别为 11 min、21 min 和 51 min。

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LM-4108 Chemical Structure

LM-4108 Chemical Structure

CAS No. : 261766-32-9

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规格 价格 是否有货 数量
1 mg ￥367
3 - 4 周
5 mg   询价  
10 mg   询价  

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LM-4108 相关抗体

Top Publications Citing Use of Products

查看 COX 亚型特异性产品:

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COX COX-1 COX-2 COX-3

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

LM-4108 (N-(2-Phenylethyl)-indomethacin amide) is a selective and orally active COX-2 inhibitor with an IC50 of 0.06 μM for purified human COX-2. LM-4108 shows anti-inflammatory activity and may be effective in prevention of cancer. Half-lives for the disappearance of 10 μM LM-4108 in rat, human, and mouse liver microsomes were 11 min, 21 min, and 51 min, respectively[1].

IC50 & Target[1]

Human COX-2

60 nM (IC50)

Ovine COX-1

>66 μM (IC50)

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
RAW264.7 IC50
0.21 μM
Compound: LM-4108
Inhibition of COX2 in mouse RAW264.7 cells by enzyme immunoassay
Inhibition of COX2 in mouse RAW264.7 cells by enzyme immunoassay
[PMID: 20056549]
RAW264.7 IC50
56.7 μM
Compound: LM-4108
Inhibition of COX1 in mouse RAW264.7 cells by enzyme immunoassay
Inhibition of COX1 in mouse RAW264.7 cells by enzyme immunoassay
[PMID: 20056549]
分子量

460.95

Formula

C27H25ClN2O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

LM-4108 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LM-4108261766-32-9N-(2-Phenylethyl)-indomethacin amideLM4108LM 4108COXCyclooxygenasecorneal angiogenesisfootpad edema modelinflammationβ-fibroblastInhibitorinhibitorinhibit

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