2. Immunology/Inflammation
  3. COX
  4. COX-2-IN-34

COX-2-IN-34 (compound 8a) 是一种选择性的、口服有效的 COX-2 抑制剂，无胃溃疡毒性，有抗炎作用。

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COX-2-IN-34 Chemical Structure

COX-2-IN-34 Chemical Structure

CAS No. : 2788578-71-0

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Customer Review

COX-2-IN-34 相关抗体

Top Publications Citing Use of Products

查看 COX 亚型特异性产品:

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COX COX-1 COX-2 COX-3

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

COX-2-IN-34 (compound 8a) is a selective and orally active inhibitor of COX-2 , with an IC50 of 0.42 μM. COX-2-IN-34 has no gastric ulcer toxicity but has anti-inflammatory effects[1].

IC50 & Target

COX-2

0.42 μM (IC50)

体外研究
(In Vitro)

COX-2-IN-34 (compound 8a) (100 μM, 24 h) 对 RAW264.7 细胞没有明显的细胞毒性[1]。
COX-2-IN-34 选择性抑制 COX-1 和 COX-2 活性，其 IC50 分别为 34.86 和 0.42 μM。10 μM 的 COX-2-IN-34 对 COX-2 的抑制效果达到 82%[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

COX-2-IN-34 相关抗体:
体内研究
(In Vivo)

COX-2-IN-34 (compound 8a) ( 口服, 50 mg/kg, 三天) 在正常雄性大鼠模型中无胃溃疡毒性[1]。
COX-2-IN-34 (皮下注射, 50 mg/kg) 在卡拉胶诱导的大鼠足跖水肿实验模型中表现出明显的抗炎作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: The Carrageenan-induced rat paw edema assay model[1]
Dosage: 50 mg/kg
Administration: Subcutaneous injection (s.c.)
Result: Expressed the reduction of edema claw volume after 0h, 1 h, 2 h, 3h, 4 h, and 6 h of carrageenan injection compared to the control group.
Exhibited superior inhibition of 42.90% and 45.95% at the 3rd and 4th hour, respectively, which was comparatively much closer in potency to that of the Celecoxib (HY-14398) group (45.18% inhibition of edema at 3h).
分子量

245.23

Formula

C13H11NO4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

COX-2-IN-34 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

COX-2-IN-342788578-71-0COXCyclooxygenaseRAW 264.7rat paw edema assay modelInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-155133
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