2. Immunology/Inflammation
  3. COX
  4. Ketoprofen (lysinate)

Ketoprofen (lysinate)  (Synonyms: RP-19583 (lysinate))

目录号: HY-B0227A
产品使用指南

摩尔计算器

Ketoprofen (RP-19583) lysinate 是一种非甾体抗炎剂，可抑制 cyclooxygenase 的活性，其 IC50 值为 2 nM (COX-1) 和 26 nM (COX-2)。Ketoprofen lysinate 可用于炎症、免疫学和代谢性疾病 (如肥胖) 的相关研究。

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Ketoprofen (lysinate) Chemical Structure

Ketoprofen (lysinate) Chemical Structure

CAS No. : 57469-78-0

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Ketoprofen (lysinate) 的其他形式现货产品:

Customer Review

Other Forms of Ketoprofen (lysinate):

Ketoprofen (lysinate) 相关抗体

Top Publications Citing Use of Products

查看 COX 亚型特异性产品:

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COX COX-1 COX-2 COX-3

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ketoprofen (RP-19583) lysinate is a non-steroidal anti-inflammatory agent. Ketoprofen lysinate can inhibit the activity of cyclooxygenase with IC50 values of 2 nM (COX-1) and 26 nM (COX-2). which is potential in the research of inflammation, immunology, and metabolic disease such as obesity[1][2][3].

IC50 & Target

COX-1

2 nM (IC50)

COX-2

26 nM (IC50)

体外研究
(In Vitro)

Ketoprofen lysinate inhibits COX in LPS-stimulated monocytes isolated from human blood, with IC50 values of 2 nM (COX-1) and 26 nM (COX-2)[1].
Ketoprofen lysinate (2.5 mg /mL, 3-24h) decreases the mRNA level of immune factors (TNFα, IL-8, SAA and COX-2) and PTGES in LPS-stimulated bovine mammary epithelial cells[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Ketoprofen (lysinate) 相关抗体:

RT-PCR[3]

Cell Line: LPS (0.2 μg/mL)-stimulated bovine mammary epithelial cells
Concentration: 2.5 mg /mL
Incubation Time: 3, 6, 24 h
Result: Decreased the mRNA level of TNFα, IL-8, SAA, COX-2 and PTGES.
体内研究
(In Vivo)

Ketoprofen lysinate (Oral administration, 10 mg/kg, three times a week for 10 weeks, HFD-induced obese C57BL/6 mice) decreases in relative body weight (15.41%), the iWAT mass (approximately 41%), and leptin (58.68%) and resistin (12.88%)[2].
Ketoprofen lysinate (50 mg/kg, LPS-treated dairy cows) lowers the increase of somatic cell count (SCC), serum albumin (SA), IgG and lactate dehydrogenase (LDH) activity in milk induced by LPS[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: HFD-induced obese C57BL/6 mice[2]
Dosage: 10 mg/kg
Administration: Oral administration, three times a week for 10 weeks
Result: Decreased in relative body weight, the iWAT mass, and the level of leptin and resistin.
Animal Model: LPS (0.2 μg/mL)-treated dairy cows [3]
Dosage: 50 mg/kg
Administration: Injection (Milk samples were taken every 30 min until 6 and 9 h)
Result: Lowered the increase of somatic cell count (SCC), serum albumin (SA), IgG and lactate dehydrogenase (LDH) activity in milk.
Clinical Trial
分子量

400.47

Formula

C22H28N2O5
CAS 号
中文名称

赖氨酸酮基布洛芬
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Ketoprofen (lysinate) 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ketoprofen (lysinate)57469-78-0RP-19583 (lysinate)赖氨酸酮基布洛芬COXCyclooxygenaseAnti-inflammatory agentsCOX inhibitorobesityHFD-induced obese mice3T3-L1 cellwhite adipocytesInhibitorinhibitorinhibit

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