Pectolinarigenin (Synonyms: 柳穿鱼黄素)

目录号: HY-N0493 纯度: 99.59%: FAQs
Data Sheet SDS COA 产品使用指南

摩尔计算器

Pectolinarigenin 是 COX-2/5-LOX 的双重抑制剂。具有抗炎活性。Pectolinarigenin 对黑素生成具有有效的抑制作用。

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Pectolinarigenin Chemical Structure

CAS No. : 520-12-7

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规格	价格	是否有货
1 mg	￥476	In-stock
5 mg	￥1190	In-stock
10 mg	￥2020	In-stock
20 mg	￥3430	In-stock
50 mg		询价
100 mg		询价

or 大包装询价

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Customer Review

Other Forms of Pectolinarigenin:

Pectolinarigenin (Standard) 询价

MCE 顾客使用本产品发表的 1 篇科研文献

•Chem Biol Interact. 2023 Oct 11:110763. [Abstract]

Pectolinarigenin 相关产品

•相关化合物库:

•同靶点产品:

•同靶点蛋白产品:

查看 COX 亚型特异性产品:

查看所有亚型

COX COX-1 COX-2 COX-3

查看 Lipoxygenase 亚型特异性产品:

查看所有亚型

5-LOX 12-LOX 15-LOX

生物活性
纯度 & 产品资料
参考文献

生物活性

Pectolinarigenin is a dual inhibitor of COX-2/5-LOX. Anti-inflammatory activity^[1]. Pectolinarigenin has potent inhibitory activities on melanogenesis^[2].

IC₅₀ & Target^[1]

COX-2

5-LOX

细胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
A-375	IC₅₀	8.2 μM Compound: 2	Antiproliferative activity against human A375 cells after 48 hrs by sulforhodamine B assay Antiproliferative activity against human A375 cells after 48 hrs by sulforhodamine B assay	[PMID: 18818071]
A549	IC₅₀	5.6 μM Compound: 2	Antiproliferative activity against human A549 cells after 48 hrs by sulforhodamine B assay Antiproliferative activity against human A549 cells after 48 hrs by sulforhodamine B assay	[PMID: 18818071]
ACHN	IC₅₀	15.2 μM Compound: 2	Antiproliferative activity against human ACHN cells after 48 hrs by sulforhodamine B assay Antiproliferative activity against human ACHN cells after 48 hrs by sulforhodamine B assay	[PMID: 18818071]
C32	IC₅₀	7 μM Compound: 2	Antiproliferative activity against human C32 cells after 48 hrs by sulforhodamine B assay Antiproliferative activity against human C32 cells after 48 hrs by sulforhodamine B assay	[PMID: 18818071]
Caco-2	IC₅₀	5.3 μM Compound: 2	Antiproliferative activity against human Caco-2 cells after 48 hrs by sulforhodamine B assay Antiproliferative activity against human Caco-2 cells after 48 hrs by sulforhodamine B assay	[PMID: 18818071]
COR-L23	IC₅₀	4.1 μM Compound: 2	Antiproliferative activity against human COR-L23 cells after 48 hrs by sulforhodamine B assay Antiproliferative activity against human COR-L23 cells after 48 hrs by sulforhodamine B assay	[PMID: 18818071]
HepG2	IC₅₀	18.1 μM Compound: 2	Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay	[PMID: 30579802]
Jurkat	IC₅₀	> 20 μM Compound: 2	Immunosuppressive activity in human Jurkat cells assessed as reduction in PHA + PMA-induced IL-2 production after 48 hrs by ELISA Immunosuppressive activity in human Jurkat cells assessed as reduction in PHA + PMA-induced IL-2 production after 48 hrs by ELISA	[PMID: 30579802]
L6	IC₅₀	20.2 μM Compound: 24	Cytotoxicity against rat L6 cells after 72 hrs by alamar blue staining based fluorescence assay Cytotoxicity against rat L6 cells after 72 hrs by alamar blue staining based fluorescence assay	[PMID: 29244495]
MOLM-13	IC₅₀	5.9 μM Compound: 32	Cytotoxicity against human MOLM-13 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay Cytotoxicity against human MOLM-13 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay	[PMID: 33393294]
MV4-11	IC₅₀	7.9 μM Compound: 32	Cytotoxicity against human MV4-11 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay Cytotoxicity against human MV4-11 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay	[PMID: 33393294]
NCI-H1975	IC₅₀	76.6 μM Compound: 2	Cytotoxicity against human NCI-H1975 cells after 72 hrs by MTT assay Cytotoxicity against human NCI-H1975 cells after 72 hrs by MTT assay	[PMID: 30579802]
PC-9	IC₅₀	> 80 μM Compound: 2	Cytotoxicity against human PC9 cells after 72 hrs by MTT assay Cytotoxicity against human PC9 cells after 72 hrs by MTT assay	[PMID: 30579802]
RAW264.7	IC₅₀	> 20 μM Compound: 2	Anti-inflammatory activity in mouse RAW264.7 cells assessed as reduction in LPS-induced TNF-alpha production after 48 hrs by ELISA Anti-inflammatory activity in mouse RAW264.7 cells assessed as reduction in LPS-induced TNF-alpha production after 48 hrs by ELISA	[PMID: 30579802]
RAW264.7	IC₅₀	> 20 μM Compound: 2	Anti-inflammatory activity in mouse RAW264.7 cells assessed as reduction in LPS-induced IL-6 production after 48 hrs by ELISA Anti-inflammatory activity in mouse RAW264.7 cells assessed as reduction in LPS-induced IL-6 production after 48 hrs by ELISA	[PMID: 30579802]
Sf9	IC₅₀	0.6 μM Compound: 1	Inhibition of N-terminal GST-His-tagged c-KIT (544 to 976 amino acids) D816V mutant (unknown origin) expressed in Sf9 insect cells using poly[Glu:Tyr] (4:1) as substrate preincubated for 20 mins followed by [33P-gamma]ATP addition and subsequent inhibitio Inhibition of N-terminal GST-His-tagged c-KIT (544 to 976 amino acids) D816V mutant (unknown origin) expressed in Sf9 insect cells using poly[Glu:Tyr] (4:1) as substrate preincubated for 20 mins followed by [33P-gamma]ATP addition and subsequent inhibitio	[PMID: 26807861]

分子量

314.29

Formula

C₁₇H₁₄O₆

CAS 号

520-12-7

性状

固体

颜色

Light yellow to yellow

中文名称

柳穿鱼黄素

结构分类

初始来源

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据

细胞实验：

DMSO 中的溶解度 : 33.33 mg/mL (106.05 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.1818 mL	15.9089 mL	31.8177 mL
5 mM	0.6364 mL	3.1818 mL	6.3635 mL
10 mM	0.3182 mL	1.5909 mL	3.1818 mL

查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

摩尔计算器
稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)

体积 _(start)

浓度 _(final)

体积 _(final)

动物实验：

请根据您的实验动物和给药方式选择适当的溶解方案。

以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；
以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

方案一

请依序添加每种溶剂： 2% DMSO 98% (20% SBE-β-CD in Saline)
Solubility: ≥ 1 mg/mL (3.18 mM); 澄清溶液

以下溶解方案，请直接配制工作液。建议现用现配，在短期内尽快用完。以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶。

方案一

请依序添加每种溶剂： 50% PEG300 50% Saline
Solubility: 1 mg/mL (3.18 mM); 悬浊液; 超声助溶 (<60°C)

动物溶解方案计算器

请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

每只动物的给药体积

μL

动物数量

只

由于实验过程有损耗，建议您多配一只动物的量

请输入您的动物体内配方组成：

DMSO +

Tween-80 +

Saline

如果您的动物是免疫缺陷鼠或者体弱鼠，建议 DMSO 中的在最后工作液体系中的占比尽量不超过 2%。

方案所需 助溶剂 包括：DMSO，，均可在 MCE 网站选购。，Tween 80，均可在 MCE 网站选购。

计算结果

工作液所需浓度 : mg/mL

储备液配制方法 : mg 药物溶于 μL DMSO（母液浓度为 mg/mL）。

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

您所需的储备液浓度超过该产品的实测溶解度，以下方案仅供参考，如有需要，请与 MCE 中国技术支持联系。

动物实验体内工作液的配制方法 : 取 μL DMSO 储备液，加入 μL 。 μL ，混合均匀至澄清，再加 μL Tween 80，混合均匀至澄清，再加 μL 生理盐水。

连续给药周期超过半月以上，请谨慎选择该方案。

请确保第一步储备液溶解至澄清状态，从左到右依次添加助溶剂。您可采用超声加热（超声清洗仪，建议频次 20-40 kHz），涡旋吹打等方式辅助溶解。

纯度 & 产品资料

纯度: 99.59%

选择批次：

Data Sheet (612 KB) SDS (252 KB)

COA (286 KB) HNMR (255 KB) LCMS (267 KB)

产品使用指南 (1538 KB)

参考文献

[1]. Lim H, et al. Anti-inflammatory activity of pectolinarigenin and pectolinarin isolated from Cirsium chanroenicum. Biol Pharm Bull. 2008 Nov;31(11):2063-7. [Content Brief]

[2]. Lee S, et al. Pectolinarigenin, an aglycone of pectolinarin, has more potent inhibitory activities on melanogenesis than pectolinarin.Biochem Biophys Res Commun. 2017 Nov 4;493(1):765-772. [Content Brief]

Pectolinarigenin 相关分类

Inflammation/Immunology

完整储备液配制表

可选溶剂	浓度溶剂体积质量	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.1818 mL	15.9089 mL	31.8177 mL	79.5444 mL
	5 mM	0.6364 mL	3.1818 mL	6.3635 mL	15.9089 mL
	10 mM	0.3182 mL	1.5909 mL	3.1818 mL	7.9544 mL
	15 mM	0.2121 mL	1.0606 mL	2.1212 mL	5.3030 mL
	20 mM	0.1591 mL	0.7954 mL	1.5909 mL	3.9772 mL
	25 mM	0.1273 mL	0.6364 mL	1.2727 mL	3.1818 mL
	30 mM	0.1061 mL	0.5303 mL	1.0606 mL	2.6515 mL
	40 mM	0.0795 mL	0.3977 mL	0.7954 mL	1.9886 mL
	50 mM	0.0636 mL	0.3182 mL	0.6364 mL	1.5909 mL
	60 mM	0.0530 mL	0.2651 mL	0.5303 mL	1.3257 mL
	80 mM	0.0398 mL	0.1989 mL	0.3977 mL	0.9943 mL
	100 mM	0.0318 mL	0.1591 mL	0.3182 mL	0.7954 mL

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pectolinarigenin520-12-7柳穿鱼黄素COXLipoxygenaseCyclooxygenaseLOXcyclooxygenaselipoxygenaseCOX-25-LOXanti-inflammationmelanogenesisInhibitorinhibitorinhibit

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

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上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

Pectolinarigenin (Synonyms: 柳穿鱼黄素)

Customer Review

Other Forms of Pectolinarigenin:

MCE 顾客使用本产品发表的 1 篇科研文献