2. 一站式药筛
  3. 化合物库
  4. 生物活性化合物库系列
  5. 信号通路化合物库系列
  6. 代谢酶化合物库
代谢酶化合物库 - Metabolic Enzyme Compound Library

Cat. No.: HY-L146

代谢 (metabolism) 是生物体内一系列化学反应的总称，维持着细胞稳态。代谢途径是酶介导的一系列生化反应，可以促使细胞或组织内化合物的生物合成(合成代谢)或分解(分解代谢)，包括葡萄糖代谢、脂质代谢、蛋白质代谢等。作为代谢中的催化剂，酶在生物体代谢中发挥重要作用——既能促使反应加快，也能调节代谢反应的速率。由于代谢平衡在生物体的重要性，代谢酶的功能异常常导致多种代谢类疾病的发生，如糖尿病、肥胖、心血管疾病等。

MCE 收录了 2,955 个代谢酶相关的小分子化合物，是研究生物体代谢活动及进行代谢类疾病药物开发的重要工具。

我们将在明确您的产品用途后，向符合资质的客户通过定制合成服务的方式提供 MCE 代谢酶化合物库，我们为该库中的所有产品提供溶液包装或粉末包装。溶液包装中，2,894 个产品以 10 mM 浓度提供，51 个产品以 2 mM 浓度提供，10 个产品以 3 mg/mL 浓度提供。

溶液包装中，我们对于溶液状态稳定且溶解度不低于 10 mM 的产品，提供 10 mM 溶液；对于溶液状态稳定且溶解度介于 2~10 mM 的产品，我们提供 2 mM 溶液；对于溶液状态稳定、分子量不确定且溶解度不低于 3 mg/mL产品，我们提供 3 mg/mL 溶液。

  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack
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MCE 顾客使用化合物库产品发表的文献

  • 生物活性
  • 产品详情
  • 化合物库组成

活性描述 & 特点

Biological Activity

•    A unique collection of 2,955 metabolic enzymes related compounds for high throughput screening (HTS) and high content screening (HCS).

•   The compound library targets metabolic enzymes of glucose Metabolism, Lipid Metabolism, Amino Acid/Protein Metabolism, Nucleic Acid Metabolism.

•   A useful tool for the discovery of compounds for metabolism diseases.

•   Bioactivity and safety confirmed by preclinical research and clinical trials. Some have been approved by FDA.

•   Structurally diverse, bioactive, and cell permeable.

•   More detailed compound information with structure, IC50, and other chemical & biological data.

•   High purity and quality validated by NMR and LC/MS.

•   All compounds are in stock and continuously updated.

产品详情

Product Details

Formulation:

A collection of 2,955 fatty acids compounds supplied as pre-dissolved Solutions or Solid.
Solution: 2,894 compounds supplied in 10 mM solution, 51 compounds supplied in 2 mM solution, 10 compounds supplied in 3 mg/mL solution.

Layout:

96-well storage tube or 96-well plate: 1st and 12th column are left empty.
384-well plate: the first two columns and the last two columns are left empty.
Compounds with different concentrations or dissolved in different solvents will be put on separate plates. This way of layout may increase the number of plates because there could be three solvents and three concentrations.
If you have other requirements, please let us know.

Container:

96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode.

Storage:

-80°C

Shipping:

Blue ice or dry ice

化合物库组成

Composition

PPAR (123)

HSP (88)

GSK-3 (75)

COX (49)

ROR (31)

LXR (30)

FAAH (29)

HIV (29)

FXR (28)

MAGL (25)

SHP2 (23)

Akt (22)

CDK (22)

GLUT (20)

NAMPT (19)

PAI-1 (18)

PI3K (13)

ERK (12)

Wnt (12)

PKC (11)

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  •  特定化合物
  •  化合物数量
  •  产品排布图
  •  浓度
  •  形式（固体或溶液）
  •  YES
联系专家定制
  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack
  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack

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    产品名称：
    Metabolic Enzyme Compound Library
    目录号：
    HY-L146
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