2. 一站式药筛
  3. 化合物库
  4. 生物活性化合物库系列
  5. 信号通路化合物库系列
  6. 线粒体靶向化合物库
线粒体靶向化合物库 - Mitochondria-Targeted Compound Library

Cat. No.: HY-L089

线粒体在细胞的许多重要进程中发挥关键作用，包括能量产生、脂肪酸氧化、三羧酸 (TCA) 循环、钙信号传导、通透性改变、凋亡和热产生等。越来越多的研究表明，许多疾病的发生都与线粒体功能受损有关，如 ROS（活性氧）积累增加，氧化磷酸化及 ATP 产生减少。目前，线粒体被认为是癌症、心血管疾病、神经相关疾病新药设计的重要靶点之一。一些小分子药物或生物制剂可以通过多种途径作用于线粒体，包括抑制电子传递链、氧化磷酸化解偶联、线粒体 Ca2+ 调节以及通过减少或增加线粒体 ROS 积累来控制氧化应激等。

MCE 收录了 970 种线粒体靶向化合物，主要靶点涉及线粒体代谢、ATP合酶（ATP合酶）、线粒体自噬（Mitophagy）、活性氧（ROS）等。MCE线粒体靶向库是进行线粒体相关药物开发及相关研究的重要工具。

我们将在明确您的产品用途后，向符合资质的客户通过定制合成服务的方式提供 MCE 线粒体靶向化合物库，我们为该库中的所有产品提供溶液包装或粉末包装。溶液包装中，955 个产品以 10 mM 浓度提供，13 个产品以 2 mM 浓度提供，2 个产品以 3 mg/mL 浓度提供。

溶液包装中，我们对于溶液状态稳定且溶解度不低于 10 mM 的产品，提供 10 mM 溶液；对于溶液状态稳定且溶解度介于 2~10 mM 的产品，我们提供 2 mM 溶液；对于溶液状态稳定、分子量不确定且溶解度不低于 3 mg/mL产品，我们提供 3 mg/mL 溶液。

  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack
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Compound Screening Libraries

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MCE 顾客使用化合物库产品发表的文献

  • 生物活性
  • 产品详情
  • 化合物库组成

活性描述 & 特点

Biological Activity

•   A unique collection of 970 mitochondria-targeted compounds for high throughput screening (HTS) and high content screening (HCS).

•   Targets such as Mitochondrial Metabolism, ATP Synthase, Mitophagy, Reactive Oxygen Species, etc.

•   A useful tool for drug discovery of mitochondria-related diseases.

•   Bioactivity and safety confirmed by preclinical research and /or clinical trials. Some inhibitors have been approved by FDA.

•   Structurally diverse, medicinally active, and cell permeable.

•   More detailed compound information with structure, IC50, and brief introduction.

•   High purity and quality validated by NMR and LC/MS.

•   All compounds are in stock and continuously updated.

产品详情

Product Details

Formulation:

A collection of 970 Mitochondria-Targeted compounds supplied as pre-dissolved Solutions or Solid.
Solution: 955 compounds supplied in 10 mM solution, 13 compounds supplied in 2 mM solution, 2 compounds supplied in 3 mg/mL solution.

Layout:

96-well storage tube or 96-well plate: 1st and 12th column are left empty.
384-well plate: the first two columns and the last two columns are left empty.
Compounds with different concentrations or dissolved in different solvents will be put on separate plates. This way of layout may increase the number of plates because there could be three solvents and three concentrations.
If you have other requirements, please let us know.

Container:

96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode.

Storage:

-80°C

Shipping:

Blue ice or dry ice

化合物库组成

Composition

COX (16)

PARP (15)

HIV (14)

Akt (13)

AMPK (10)

IKK (10)

PDHK (10)

PI3K (8)

PPAR (7)

HSV (6)

mTOR (6)

Wnt (5)

CDK (4)

EGFR (4)

HSP (4)

JAK (4)

JNK (4)

STAT (4)

AP-1 (3)

ERK (3)

HBV (3)

HDAC (3)

MMP (3)

p62 (3)

PKC (3)

SOD (3)

相关服务推荐
定制您专属的化合物库
  •  特定化合物
  •  化合物数量
  •  产品排布图
  •  浓度
  •  形式（固体或溶液）
  •  YES
联系专家定制
  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack
  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack

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    HY-L089
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