2. Anti-infection Apoptosis NF-κB Immunology/Inflammation MAPK/ERK Pathway
  3. Dengue virus Flavivirus TNF Receptor NF-κB NO Synthase COX JNK p38 MAPK IKK
  4. Lucidone

Lucidone 是一种抗炎剂，能够从红果木犀果实中分离得到。Lucidone 抑制 RAW 264.7 小鼠巨噬细胞中 LPS 诱导 NO 和 PGE2 的产生。Lucidone 还降低肿瘤坏死因子 TNF-α 分泌，iNOS 和 COX-2 表达。Lucidone 阻止 NF-κB 易位，抑制 JNK 和 p38MAPK 信号。Lucidone 对登革热病毒病毒 (DENV) 也有抑制活性 (EC50=25 μM)。

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Lucidone Chemical Structure

Lucidone Chemical Structure

CAS No. : 19956-53-7

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规格 是否有货
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Lucidone 相关抗体

Top Publications Citing Use of Products

查看 TNF Receptor 亚型特异性产品:

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TNFRSF1A/CD120a TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF7/CD27 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

查看 NF-κB 亚型特异性产品:

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

查看 NO Synthase 亚型特异性产品:

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nNOS iNOS eNOS

查看 COX 亚型特异性产品:

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COX COX-1 COX-2 COX-3

查看 JNK 亚型特异性产品:

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JNK1 JNK2 JNK3 JNK

查看 p38 MAPK 亚型特异性产品:

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p38 MAPK p38α p38β MAPK13 p38δ p38γ

查看 IKK 亚型特异性产品:

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IKK-α IKK-β IKK IKKε TBK1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Lucidone, an anti-inflammatory agent that can be isolated from the fruit of Lindera erythrocarpa Makino. Lucidone inhibits LPS-induced NO and PGE2 production in RAW 264.7 mouse macrophages. Lucidone also decreases TNF-α secretion, iNOS and COX-2 expression. Lucidone prevents NF-κB translocation and inhibits JNK and p38MAPK signals. Lucidone also has inhibitory activity against Dengue virus (DENV) (EC50=25 μM)[1][2].

IC50 & Target[1]

p38 MAPK

 

JNK

 

p50

 

p65

 

COX-2

 

NF-κB

 

iNOS

 

IKK

 

体外研究
(In Vitro)

Lucidone (10 μg/mL, 25 μg/mL; 1 h 或 20 h) 降低 RAW 264.7 巨噬细胞受 LPS (1 μg/mL) 诱导而导致 TNF-α 分泌 (20 h) 以及 PGE2 产量 (1 h) 的增加[1]。
Lucidone (10 μg/mL, 25 μg/mL; 8 h) 抑制 RAW 264.7 巨噬细胞受 LPS (1 μg/mL) 诱导而导致的 iNOS 和 COX-2 表达的增加[1]。
Lucidone (10 μg/mL, 25 μg/mL; 1 h) 抑制 RAW 264.7 巨噬细胞受 LPS (1 μg/mL) 诱导而导致的 NF-κB p65/p50 水平的增加，以及 IKK 蛋白的磷酸化[1]。
Lucidone (0-40 μM; 3 d) 降低感染 Huh-7 细胞中 DENV 的病毒滴度[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Lucidone 相关抗体:

Western Blot Analysis[1]

Cell Line: RAW 264.7 macrophages
Concentration: 5 μg/mL, 10 μg/mL, 25 μg/mL
Incubation Time: 1 hour
Result: Inhibited LPS-induced NF-κB nuclear translocation, decreased the level of p65 and of the p50 subunits at 10 μg/mL and 25 μg/mL.
Inhibited the phosphorylation of IKK at 10 μg/mL and 25 μg/mL.

Cell Viability Assay[2]

Cell Line: Huh-7 cells infected with DENV
Concentration: 5 μM, 10 μM, 20 μM, and 40 μM
Incubation Time: 3 days
Result: Showed no significant cell viability on Huh-7 cells, while leading to a decrease on viral load of DENV.
体内研究
(In Vivo)

Lucidone (1 mg/kg; 颅内注射; 一周内 3 次) 显著提高 DENV 感染小鼠的存活率和体重[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: DENV-infected ICR mice[2]
Dosage: 0.4 mg/kg, 1 mg/kg
Administration: Intracranial injection; 3 times dose at day 2, 4, 6 after DENV infection
Result: Increased the survival rate and body weight of DENV-infected mice on day 7.
分子量

256.25

Formula

C15H12O4
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Lucidone 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lucidone19956-53-7Dengue virusFlavivirusTNF ReceptorNF-κBNO SynthaseCOXJNKp38 MAPKIKKDENVTumor Necrosis Factor ReceptorTNFRNuclear factor-κBNuclear factor-kappaBNitric oxide synthasesNOSCyclooxygenasec-Jun N-terminal kinaseIκB kinaseI kappa B kinaseInhibitorinhibitorinhibit

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