Dendrophenol (Synonyms: 石斛酚; Moscatilin)

目录号: HY-N6031 纯度: 99.63%: FAQs
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Dendrophenol (Moscatilin) 是一种 NF-κB 抑制剂，可抑制炎症反应。Dendrophenol 对多种肿瘤细胞具有杀伤作用，可诱导细胞周期阻滞和凋亡 (apoptosis)。Dendrophenol 具有抗肿瘤的活性。此外，Dendrophenol 可抑制血管钙化。

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Dendrophenol Chemical Structure

CAS No. : 108853-14-1

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

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COX COX-1 COX-2 COX-3

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JNK1 JNK2 JNK3 JNK

生物活性
纯度 & 产品资料
参考文献

生物活性

Dendrophenol (Moscatilin) is a NF-κB inhibitor that inhibits inflammation. Dendrophenol exerts potent cytotoxic effect against tumor cells and induces cell cycle arrest and apoptosis. Dendrophenol has antitumor activity. In addition, Dendrophenol can inhibit vascular calcification^[1]^[2]^[3]^[4].

IC₅₀ & Target^[1]

NF-κB

COX-2

HIF-1α

细胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
A549	IC₅₀	2.1 μM Compound: 23MST; MST	Antiproliferative activity against human A549 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human A549 cells incubated for 72 hrs by MTT assay	[PMID: 31047774]
FaDu	IC₅₀	2.55 μM Compound: 1	Cytotoxicity against human FaDu cells assessed as cell viability incubated for 24 hrs by CCK-8 assay Cytotoxicity against human FaDu cells assessed as cell viability incubated for 24 hrs by CCK-8 assay	[PMID: 32711292]
HCCLM3	IC₅₀	2.092 μM Compound: 24	Antiproliferative activity against human HCCLM3 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against human HCCLM3 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 34931827]
HCT-116	IC₅₀	2.29 μM Compound: 23MST; MST	Antiproliferative activity against human HCT116 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human HCT116 cells incubated for 72 hrs by MTT assay	[PMID: 31047774]
HepG2	IC₅₀	3.02 μM Compound: 24	Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 34931827]
HepG2	IC₅₀	3.76 μM Compound: 23MST; MST	Antiproliferative activity against human HepG2 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human HepG2 cells incubated for 72 hrs by MTT assay	[PMID: 31047774]
MDA-MB-231	IC₅₀	0.082 μM Compound: 23MST; MST	Antiproliferative activity against human MDA-MB-231 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells incubated for 72 hrs by MTT assay	[PMID: 31047774]
MKN-45	IC₅₀	3.51 μM Compound: 23MST; MST	Antiproliferative activity against human MKN45 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human MKN45 cells incubated for 72 hrs by MTT assay	[PMID: 31047774]
N2a	IC₅₀	> 20 μM Compound: Mos	Cytotoxicity against mouse Neuro2a cells assessed as reduction in cell viability after 12 hrs by MTT assay Cytotoxicity against mouse Neuro2a cells assessed as reduction in cell viability after 12 hrs by MTT assay	[PMID: 31291099]
N2a	IC₅₀	> 20 μM Compound: Mos	Cytotoxicity against mouse Neuro2a cells assessed as reduction in cell viability after 24 hrs by MTT assay Cytotoxicity against mouse Neuro2a cells assessed as reduction in cell viability after 24 hrs by MTT assay	[PMID: 31291099]
Platelet	IC₅₀	61.8 μM Compound: 1	Antiplatelet activity against washed rabbit platelet assessed as inhibition of arachidonic acid-induced platelet aggregation preincubated for 3 mins by turbidimetric method Antiplatelet activity against washed rabbit platelet assessed as inhibition of arachidonic acid-induced platelet aggregation preincubated for 3 mins by turbidimetric method	[PMID: 7798962]
RAW264.7	IC₅₀	4.4 μM Compound: 1	Cytotoxicity against mouse RAW264.7 cells assessed as decrease in cell proliferation rate after 24 hrs by MTS assay Cytotoxicity against mouse RAW264.7 cells assessed as decrease in cell proliferation rate after 24 hrs by MTS assay	[PMID: 27777005]
SH-SY5Y	IC₅₀	> 20 μM Compound: Mos	Cytotoxicity against human SH-SY5Y cells assessed as reduction in cell viability after 12 hrs by MTT assay Cytotoxicity against human SH-SY5Y cells assessed as reduction in cell viability after 12 hrs by MTT assay	[PMID: 31291099]
SH-SY5Y	IC₅₀	> 20 μM Compound: Mos	Cytotoxicity against human SH-SY5Y cells assessed as reduction in cell viability after 24 hrs by MTT assay Cytotoxicity against human SH-SY5Y cells assessed as reduction in cell viability after 24 hrs by MTT assay	[PMID: 31291099]

体外研究
(In Vitro)

Dendrophenol (5-100 μM；1 小时) 在 LPS (HY-D1056) 处理的巨噬细胞中，抑制 COX-2、iNOS、HIF-1α 和 NF-κB 的表达和抑制细胞活化^[1]。
Dendrophenol (0-50 μM；15 小时-6 天) 对来自胎盘、肺和胃的肿瘤细胞系具有较强的杀伤作用，可引起细胞 G2 期阻滞^[2]。
Dendrophenol (1 μM；4 天) 在磷酸盐处理的人主动脉平滑肌细胞中通过 WNT3/β-catenin 通路降低钙沉积，并通过 IL13RA2 和 STAT3 减少钙化诱导的炎症反应^[3]。
Dendrophenol (3-30 μM；24 小时) 通过微管蛋白解聚和 DNA 损伤应激以及 JNK 信号通路诱导人结肠癌细胞 HCT-116 凋亡^[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:	LPS (HY-D1056) treated RAW264.7 cells
Concentration:	10, 30, 50 and 100 μM
Incubation Time:	1 h
Result:	Inhibited the levels of COX-2 and iNOS in a concentration‐dependent manner.

Western Blot Analysis^[3]

Cell Line:	Phosphate treated HASMCs
Concentration:	1 μM
Incubation Time:	4 days
Result:	Reduced the levels of WNT3 and β-catenin. Increased the level of IL13RA2. Reduced the levels of p-STAT3, IL-1β and IL-6.

Western Blot Analysis^[4]

Cell Line:	HCT-116 cells
Concentration:	3, 10 and 30 μM
Incubation Time:	24 h
Result:	Increased the phosphorylation level of JNK1/2.

体内研究
(In Vivo)

Dendrophenol (10 mg/kg；腹腔注射；3 周) 在小鼠血管钙化模型中具有改善作用^[3] 。
Dendrophenol (50-100 mg/kg；腹腔注射；一周5次；2 周) 在小鼠肿瘤模型具有抗肿瘤的作用^[4] 。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Nicotine and Vitamin D3 (HY-15398) treated male C57BL/6J mice aged 25 weeks old^[3]
Dosage:	10 mg/kg
Administration:	Intraperitoneal injection (i.p.); 3 weeks
Result:	Reduced calcium accumulation in the thoracic aorta and aortic valves of the mice. Reduced the expression of calcification-related genes, such as ALPL, BMP2 and RUNX2.

Animal Model:	HCT-116 cells treated male severe combined immunodeficient mice^[4]
Dosage:	50 and 100 mg/kg
Administration:	Intraperitoneal injection (i.p.); five times a week for two weeks
Result:	Significantly inhibited tumor growth and did not result in weight loss.

分子量

304.34

Formula

C₁₇H₂₀O₅

CAS 号

108853-14-1

性状

固体

颜色

White to off-white

中文名称

石斛酚

结构分类

初始来源

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

纯度 & 产品资料

纯度: 99.63%

选择批次：

Data Sheet (551 KB) SDS (251 KB)

COA (263 KB) HNMR (200 KB) RP-HPLC (266 KB)

产品使用指南 (1538 KB)

参考文献

[1]. Liu YN, et al. Moscatilin repressed lipopolysaccharide-induced HIF-1alpha accumulation and NF-kappaB activation in murine RAW264.7 cells. Shock. 2010 Jan;33(1):70-5. [Content Brief]

[2]. Ho CK, et al. Moscatilin from the orchid Dendrobrium loddigesii is a potential anticancer agent. Cancer Invest. 2003;21(5):729-36. [Content Brief]

[3]. Zhang T, et al. Moscatilin inhibits vascular calcification by activating IL13RA2-dependent inhibition of STAT3 and attenuating the WNT3/β-catenin signalling pathway. J Adv Res. 2024 Mar 2:S2090-1232(24)00082-1. [Content Brief]

[4]. Chen TH, et al. Moscatilin induces apoptosis in human colorectal cancer cells: a crucial role of c-Jun NH2-terminal protein kinase activation caused by tubulin depolymerization and DNA damage. Clin Cancer Res. 2008 Jul 1;14(13):4250-8. [Content Brief]

Dendrophenol 相关分类

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稀释计算器

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The dilution calculator equation

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

Dendrophenol (Synonyms: 石斛酚; Moscatilin)

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