1. 一站式药筛
  2. 化合物库
  3. 生物活性化合物库系列
  4. 根据产品特点分类
  5. 神经保护化合物库
神经保护化合物库 - Neuroprotective Compound Library

Cat. No.: HY-L070

神经退行性疾病是以神经元进行性功能障碍和死亡为特征的一种疾病,如阿尔茨海默病、帕金森病和多发性硬化症 (MS) 等。神经保护是在神经退行性疾病中保护神经元使其不受不同病理因素损伤的一种方法。常用的神经保护剂通常为一些靶向神经保护通路中关键靶点的阻断剂和激动剂,如钙离子通道或钠离子通道阻断剂,GABA 受体激动剂,NMDA 受体拮抗剂等。虽然目前神经保护剂不能逆转已有的损伤,但它们可以防止进一步的神经损伤,减缓中枢神经系统的退化,在神经退行性疾病的治疗中仍然发挥重要作用。

MCE 收录了 1,153 种具有潜在神经保护作用的化合物,这些化合物主要靶向神经保护通路中的主要靶点,如钙离子通道,钠离子通道,腺苷 A1 受体等。MCE 神经保护化合物库是开发神经保护药物,研究神经保护机制的有效工具。

我们将在明确您的产品用途后,向符合资质的客户通过定制合成服务的方式提供 MCE 神经保护化合物库,我们为该库中的所有产品提供溶液包装或粉末包装。溶液包装中,1,125 个产品以 10 mM 浓度提供,25 个产品以 2 mM 浓度提供,3 个产品以 3 mg/mL 浓度提供。

溶液包装中,我们对于溶液状态稳定且溶解度不低于 10 mM 的产品,提供 10 mM 溶液;对于溶液状态稳定且溶解度介于 2~10 mM 的产品,我们提供 2 mM 溶液;对于溶液状态稳定、分子量不确定且溶解度不低于 3 mg/mL产品,我们提供 3 mg/mL 溶液。

  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack
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Compound Screening Libraries

Top Publications Citing Use of MCE Products

MCE 顾客使用化合物库产品发表的文献

  • 生物活性
  • 产品详情
  • 化合物库组成

活性描述 & 特点

Biological Activity

•   A unique collection of 1,153 compounds for high throughput screening (HTS) and high content screening (HCS).

•   Targets include calcium channel, sodium channel, adenosine A1 receptor, PI3K, etc.

•   A useful tool for exploring the mechanism of neuroprotection and discovery new drugs for neurodegenerative diseases.

•   Bioactivity and safety confirmed by preclinical research and clinical trials. Some have been approved by FDA.

•   Structurally diverse, medicinally active, and cell permeable.

•   Detailed compound information with structure, IC50, and brief introduction.

•   Validated NMR and HPLC to ensure high purity and quality.

•   All compounds are in stock and continuously updated.

产品详情

Product Details

Formulation:

A collection of 1,153 neuroprotective compounds supplied as pre-dissolved Solutions or Solid
Solution: 1,125 compounds supplied in 10 mM solution, 25 compounds supplied in 2 mM solution, 3 compounds supplied in 3 mg/mL solution.

Layout:

96-well storage tube or 96-well plate: 1st and 12th column are left empty.
384-well plate: the first two columns and the last two columns are left empty.
Compounds with different concentrations or dissolved in different solvents will be put on separate plates. This way of layout may increase the number of plates because there could be three solvents and three concentrations.
If you have other requirements, please let us know.

Container:

96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode

Storage:

-80°C

Shipping:

Blue ice or dry ice

化合物库组成

Composition

iGluR (101)

Wnt (92)

mGluR (50)

ERK (29)

Akt (27)

COX (24)

mAChR (15)

PI3K (15)

PARP (13)

GSK-3 (11)

PPAR (9)

HIV (8)

CDK (7)

JNK (7)

MMP (7)

HDAC (5)

HSV (4)

STAT (4)

AMPK (3)

AP-1 (3)

EGFR (3)

HCV (3)

HSP (3)

JAK (3)

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  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack

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    产品名称:
    Neuroprotective Compound Library
    目录号:
    HY-L070
    需求量: