2. 一站式药筛
  3. 化合物库
  4. 生物活性化合物库系列
  5. 信号通路化合物库系列
  6. 细胞增殖化合物库
细胞增殖化合物库 - Cell Proliferation Compound Library

Cat. No.: HY-L201

细胞增殖是由细胞分裂引起的细胞数量增加，是一个复杂且严格调控的过程。细胞增殖通过协调进入细胞周期来调节，且增殖情况的改变与疾病的发生息息相关。进化动力学将肿瘤的生长和发展与细胞增殖、细胞死亡、突变率的变化联系起来。此外，细胞增殖也是退行性疾病的核心，这种疾病的发生往往伴随着癌细胞的加速繁殖。因此，细胞增殖水平的检测经常用于实验室研究，也越来越多地用于临床评估肿瘤侵袭性和潜在的指导护理。已有研究表明，多个关键靶点共同参与到调节细胞增殖的进程中，如CDK，E2F，pRB，β-Catenin 等等。

MCE 收集整理了 2,161 种靶向调控细胞增殖关键靶点的化合物，可用于细胞增殖机制以及药物鉴定等研究中。

我们将在明确您的产品用途后，向符合资质的客户通过定制合成服务的方式提供 MCE 细胞增殖化合物库，我们为该库中的所有产品提供溶液包装或粉末包装。溶液包装中，2,103 个产品以 10 mM 浓度提供，54 个产品以 2 mM 浓度提供，4 个产品以 3 mg/mL 浓度提供。

溶液包装中，我们对于溶液状态稳定且溶解度不低于 10 mM 的产品，提供 10 mM 溶液；对于溶液状态稳定且溶解度介于 2~10 mM 的产品，我们提供 2 mM 溶液；对于溶液状态稳定、分子量不确定且溶解度不低于 3 mg/mL产品，我们提供 3 mg/mL 溶液。

  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack
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MCE 顾客使用化合物库产品发表的文献

  • 生物活性
  • 产品详情

活性描述 & 特点

Biological Activity

•   A unique collection of 2,161 compounds with definite or potential cell proliferation regulation activity for high-throughput screening (HTS) and high-content screening (HCS).

•   The compound library targets include CDK, β-Catenin, NF-κB etc.

•   A useful tool for the discovery of compounds for cell proliferation-related disease.

•   Bioactivity and safety confirmed by preclinical research and clinical trials. Some have been approved by FDA.

•   Structurally diverse, bioactive, and cell permeable.

•   More detailed compound information with structure, IC50, and other chemical & biological data.

•   High purity and quality validated by NMR and LC/MS.

•   All compounds are in stock and continuously updated.

产品详情

Product Details

Formulation:

A collection of 2,161 cell proliferation-related compounds supplied as pre-dissolved solutions or solid.
Solution: 2,103 compounds supplied in 10 mM solution, 54 compounds supplied in 2 mM solution, 4 compounds supplied in 3 mg/mL solution.

Layout:

96-well storage tube or 96-well plate: 1st and 12th column are left empty.
384-well plate: the first two columns and the last two columns are left empty.
Compounds with different concentrations or dissolved in different solvents will be put on separate plates. This way of layout may increase the number of plates because there could be three solvents and three concentrations.
If you have other requirements, please let us know.

Container:

96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode

Storage:

-80°C

Shipping:

Blue ice or dry ice

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定制您专属的化合物库
  •  特定化合物
  •  化合物数量
  •  产品排布图
  •  浓度
  •  形式（固体或溶液）
  •  YES
联系专家定制
  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack
  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack

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    产品名称：
    Cell Proliferation Compound Library
    目录号：
    HY-L201
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