2. Apoptosis Immunology/Inflammation MAPK/ERK Pathway
  3. Apoptosis COX TNF Receptor p38 MAPK
  4. Balanophonin

Balanophonin 是一种抗炎和抗癌剂。Balanophonin 通过抑制激活的小胶质细胞诱导的凋亡 (apoptosis) 来抑制小胶质细胞激活和神经退行性变。

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Balanophonin Chemical Structure

Balanophonin Chemical Structure

CAS No. : 80286-36-8

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Balanophonin 相关抗体

Top Publications Citing Use of Products

查看 COX 亚型特异性产品:

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COX COX-1 COX-2 COX-3

查看 TNF Receptor 亚型特异性产品:

查看所有亚型
TNFRSF1A/CD120a TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF7/CD27 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

查看 p38 MAPK 亚型特异性产品:

查看所有亚型
p38 MAPK p38α p38β MAPK13 p38δ p38γ

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Balanophonin is an anti-inflammatory and anti-cancer agent. Balanophonin inhibits microglial activation and neurodegeneration via inhibiting activated microglia-induced apoptosis[1].

IC50 & Target[1]

COX-2

 

p38

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
BV-2 IC50
7.07 μM
Compound: 11
Antineuroinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay
Antineuroinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay
[PMID: 26774654]
Hep 3B2 IC50
31.5 μM
Compound: 1b
Cytotoxicity against human Hep3B cells assessed as decrease in cell viability after 48 hrs by MTT assay
Cytotoxicity against human Hep3B cells assessed as decrease in cell viability after 48 hrs by MTT assay
[PMID: 29567344]
HepG2 IC50
38.7 μM
Compound: 1b
Cytotoxicity against human HepG2 cells assessed as decrease in cell viability after 48 hrs by MTT assay
Cytotoxicity against human HepG2 cells assessed as decrease in cell viability after 48 hrs by MTT assay
[PMID: 29567344]
体外研究
(In Vitro)

Balanophonin (1-10 μM; 24 h) 在 BV2 细胞中降低 Lipopolysaccharides (LPS; HY-D1056) 介导的 TLR4 激活和 NO 生成[1]。
Balanophonin (1-10 μM; 6 h) 降低 LPS 诱导的小胶质细胞中 iNOS 和 COX2 蛋白的表达以及 TNF-α 和 IL-1β 的产生[1]。
Balanophonin (1-10 μM; 30 min) 有效抑制 MAPK 激活[1]。
Balanophonin (1-10 μM; 24 h) 通过调节 N2a 细胞中裂解的 caspase-3 和聚 ADP 核糖聚合酶 (PARP) 的裂解，抑制 LPS 激活的小胶质细胞引起的神经元细胞死亡[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Balanophonin 相关抗体:

Western Blot Analysis[1]

Cell Line: LPS-activated BV-2 cells
Concentration: 1, 5, and 10 μM
Incubation Time: 30 min for MAPKs, 6 h for iNOS and COX2 and 24 h for PGE2, TNF-α and IL-1β
Result: Downregulated TLR4. Reduced iNOS and COX2 expression. Significantly reduced the secretion of TNF-α and IL-1β. Decreased the phosphorylation of MAPKs such as pERK, pJNK, and p-p38.

Western Blot Analysis[1]

Cell Line: Neuroblastoma N2a cells
Concentration: 1, 5, and 10 μM
Incubation Time: 24 h
Result: Slightly increased Bcl-2. Inhibited caspase-3 activation and PARP cleavage.
分子量

356.37

Formula

C20H20O6
CAS 号
中文名称

蛇菰宁
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Balanophonin 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Balanophonin80286-36-8蛇菰宁ApoptosisCOXTNF Receptorp38 MAPKCyclooxygenaseTumor Necrosis Factor ReceptorTNFRneuroinflammationneuroprotectioniNOSIL-1βBV2N2aInhibitorinhibitorinhibit

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