2. Membrane Transporter/Ion Channel Neuronal Signaling Immunology/Inflammation Anti-infection
  3. TRP Channel COX Bacterial
  4. α-Spinasterol

α-Spinasterol  (Synonyms: 菠甾醇)

目录号: HY-N6962 纯度: 99.15%
COA 产品使用指南

摩尔计算器

α-Spinasterol 是一种可口服的瞬时受体电位香草酸1 ( TRPV1) 拮抗剂，也是 COX-1 和 COX-2 的抑制剂，IC50 值分别为 16.17 μM 和 7.76 μM。α-Spinasterol 具有抗菌，抗炎，抗抑郁，抗氧化,抗伤害作用，具有血脑屏障透过性，且可改善小鼠糖尿病。

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α-Spinasterol Chemical Structure

α-Spinasterol Chemical Structure

CAS No. : 481-18-5

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1 mg ￥850
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5 mg ￥2300
In-stock
10 mg ￥3565
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Customer Review

α-Spinasterol 相关抗体

Top Publications Citing Use of Products

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TRPC TRPM TRPV TRPA TRPML

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COX COX-1 COX-2 COX-3

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

α-Spinasterol is an orally taken antagonist of transient receptor potential vanilloid 1 ( TRPV1), and it's also an inhibitor of COX-1 and COX-2, with IC50 values of 16.17 μM and 7.76 μM, respectively. α-Spinasterol exhibits antibacterial, anti-inflammatory, antidepressant, and antioxidant effects, has the ability to cross the blood-brain barrier, and can improve diabetes in mice[1][2][3][4][5][6].

IC50 & Target[2]

COX-1

16.17 μM (IC50)

COX-2

7.76 μM (IC50)

TRPV1

 

体外研究
(In Vitro)

α-Spinasterol 有抑菌活性，对 E.coli，S.pneumaniae CAU0070，S.pullorum cvcc533，S.areus 的 MIC 为 0.13，0.24，1.92，3.69 nM[1]。
α-Spinastero 与头孢替福联用，抗菌效果更好[1]。
α-Spinasterol (0-0.5 ng/mL，24 h) 对肾小球系膜细胞 GMCs 具有抑制作用，IC50 为 3.9×10-12 g/mL[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

α-Spinasterol 相关抗体:

Cell Viability Assay[1]

Cell Line: E.coli, S.pneumaniae CAU0070, S.pullorum cvcc533, S.areus
Concentration: 1/8 MIC
Incubation Time: 0, 2, 4, 6, 8, 12, 24 h
Result: Suppressed all four types of bacteria, and after being exposed for 24 hours, Staphylococcus aureus could be killed, leading to a sharp decline in bacterial numbers.

Cell Viability Assay[2]

Cell Line: GMCs
Concentration: 0 and 0.5 ng/mL
Incubation Time: 24 h
Result: Suppressed cell proliferation.
体内研究
(In Vivo)

α-Spinasterol (0.5-2.5 mg/kg，口服，6 周) 降低了小鼠血清甘油三酯，改善糖尿病症状[2]。
α-Spinasterol (0.1-1 mg/kg，口服，24 h) 在小鼠术后和神经性疼痛模型中具有抗伤害性作用[3]。
α-Spinasterol (0-2 mg/kg，i.p.，单次剂量) 在小鼠中有抗抑郁作用，但没有抗焦虑作用[4]。
α-Spinasterol (0.001-10 mg/kg，i.g.，单次剂量) 显著减少 LPS (HY-D1056) 诱导的小鼠的炎症细胞浸润[5]。
α-Spinasterol (0.001-1 mg/kg，i.p.，单次剂量) 可抑制小鼠白细胞和单个核细胞，ID50为 0.006 (0.002-0.01) mg/kg和 0.004 (0.002-0.007) mg/kg[5]。
α-Spinasterol (0.001-1 mg/kg，i.p.，单次剂量) 对小鼠有抗惊厥活性，且不影响小鼠的神经肌肉力量，不损害运动协调，不改变体温[6]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Streptozotocin-induced diabetic mice[2]
Dosage: 0.5 and 2.5 mg/kg/day; 6 weeks
Administration: Oral
Result: Reduced serum triglycerides in mice, kidney weight, and urinary protein excretion, without affecting serum glucose levels.
Animal Model: Mouse postoperative pain models (surgery incision induced) or different neuropathic pain models (trauma or chemotherapy induced)[3]
Dosage: 0.1, 0.3, 1 mg/kg; 24 h
Administration: Oral
Result: Relieved post-operative pain, reduce cell infiltration in damaged tissues, alleviated some mechanical ectopic pain caused by sciatic nerve ligation and mechanical and cold ectopic pain induced by paclitaxel, without altering spontaneous or forced motor activity, causing gastric damage, or leading to changes in the liver and kidneys, and without affecting the cell viability in mouse cortical and spinal cord slices.
Inhibited COX-1 and COX-2 enzyme activity without altering the animal's body temperature.
Animal Model: Naïve male Albino Swiss mice[4]
Dosage: 0, 0.5, 1, 2 mg/kg; 0.5-2 mg/kg; single dose
Administration: Intraperitoneal injection (i.p.)
Result: Showed an anti-immobility effect in the forced swimming test on mice, with no significant changes in body temperature and no alteration in the mice's spontaneous movement activity. Showed no anti-anxiety effects in the elevated plus maze and light-dark box tests.
Animal Model: LPS(HY-D1056)-induced peritonitis in mice[5]
Dosage: 0.001-1 mg/kg; 1-10 mg/kg; single dose
Administration: i.g.
Result: Reduced inflammatory cell infiltration in LPS-injected mice.
Animal Model: Mice induced by PTZ ;Mice induced by 6 Hz [6]
Dosage: 0, 0.02, 0.1, 0.5, 1 mg/kg; single dose
Administration: Intraperitoneal injection (i.p.)
Result: Showed higher doses of 0.5 and 1 mg/kg significantly increased the threshold for chronic seizures without affecting the sensitivity of mice to the forelimb rigidity induced by PTZ. The CS50 values in the 0.5 mg/kg and 1 mg/kg groups were significantly increased. Did not affect the neuromuscular strength of the mice, did not impair motor coordination, and did not change the body temperature.
分子量

412.69

Formula

C29H48O
CAS 号
性状

固体

颜色

White to off-white

中文名称

菠甾醇
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
细胞实验： 

DMF 中的溶解度 : 2 mg/mL (4.85 mM; 超声助溶 (<60°C))

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.4231 mL 12.1156 mL 24.2313 mL
5 mM --- --- ---
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.15%

COA (288 KB) HNMR (136 KB) CNMR (126 KB) RP-HPLC (351 KB)

产品使用指南 (1538 KB)
参考文献

α-Spinasterol 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMF 1 mM 2.4231 mL 12.1156 mL 24.2313 mL 60.5782 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

α-Spinasterol481-18-5菠甾醇TRP ChannelCOXBacterialTransient receptor potential channelsCyclooxygenaseDiabetesBlood-brain barrier permeabilityAntibacterialAnti-inflammatoryAntidepressantAntioxidantAnti-injuryInhibitorinhibitorinhibit

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