2. Immunology/Inflammation
  3. COX
  4. COX-2-IN-31

COX-2-IN-31 (compound 7b) 是一种具有口服活性的COX/5-LOX 双重抑制剂，IC50 分别为 60 nM (COX-2)，0.9 μM (5-LOX)。COX-2-IN-31 还抑制跨膜蛋白 hCA IX (Ki=48.9 nM) 和 hCA XII(Ki=5.8 nM) 的酶活性。COX-2-IN-31 具有镇痛、抗炎活性。

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COX-2-IN-31 Chemical Structure

COX-2-IN-31 Chemical Structure

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COX-2-IN-31 相关抗体

Top Publications Citing Use of Products

查看 COX 亚型特异性产品:

查看所有亚型
COX COX-1 COX-2 COX-3

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

COX-2-IN-31 (compound 7b) is an orally active and dual inhibitor of COX-2 (IC50=60 nM) and 5-LOX (IC50=1.9 μM). COX-2-IN-31 also inhibits transmembrane hCA IX(Ki=48.9 nM) and hCA XII(Ki=5.8 nM) activity. COX-2-IN-31 exhibits anti-inflammatory and analgesic activity[1].

IC50 & Target[1]

COX-1

12.5 μM (IC50)

COX-2

60 nM (IC50)

体外研究
(In Vitro)

在碳酸酐酶抑制试验中，COX-2-IN-31 (compound 7b) 有效抑制 hCA IX 和 XII，Ki 值在纳摩尔范围内 (48.9 nM 和 5.8 nM)[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

COX-2-IN-31 相关抗体:
体内研究
(In Vivo)

COX-2-IN-31 (compound 7b) (10 mg/kg; 口服; 单剂量) 表现出镇痛活性，同时显着减少小鼠的扭动次数[1]。
COX-2-IN-31 (10 mg/kg; 口服; 单次剂量) 在 Carrageenan (HY-125474) 诱导的大鼠爪水肿试验中导致爪高度显着降低[1]。
COX-2-IN-31 (10 mg/kg; 口服; 单剂量) 在雄性白化病大鼠的胃组织中表现出安全性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Acetic acid writhing test in mice[1]
Dosage: 10 mg/kg
Administration: Oral gavage; single dose; 1 h.
Result: Decreased the number of writhing responses of mouse conpared with control group.
Animal Model: Carrageenan (HY-125474)-induced rat paw edema[1]
Dosage: 10 mg/kg
Administration: Oral gavage:; single dose; 1-3h
Result: Decreased the edema volume of mouse conpared with control group.
分子量

400.41

Formula

C17H16N6O4S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

COX-2-IN-31 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

COX-2-IN-31COXCyclooxygenaseAnti-inflammatoryAnalgesicCOX-2 inhibitoryAcetic acid writhing testCarrageenan-induced rat paw edemaInhibitorinhibitorinhibit

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产品名称：
COX-2-IN-31
目录号：
HY-149270
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