2. Immunology/Inflammation
  3. COX
  4. COX-1-IN-1

COX-1-IN-1 (compound 15a) 是一种具有选择性的 COX 抑制剂，IC50 值分别是 0.23 μM (COX-1) 和 >50 μM (COX-2)。COX-1-IN-1 对血小板凝结具有抑制作用。

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COX-1-IN-1 Chemical Structure

COX-1-IN-1 Chemical Structure

CAS No. : 1369503-03-6

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COX-1-IN-1 相关抗体

Top Publications Citing Use of Products

查看 COX 亚型特异性产品:

查看所有亚型
COX COX-1 COX-2 COX-3

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

COX-1-IN-1 (compound 15a) is a selective inhibitor for cyclooxygenase (COX), with IC50s of 0.23 μM (COX-1) and >50 μM (COX-2), selective index (COX-2 IC50/COX-1 IC50) is 217. COX-1-IN-1 inhibits platelet aggregation[1].

IC50 & Target

COX-1

0.23 μM (IC50)

COX-2

50 μM (IC50)

体外研究
(In Vitro)

COX-1-IN-1 抑制花生四烯酸 (AA) 诱导的血小板聚集，IC50 值是 1 μM。对细胞和血小板具有低细胞毒性 (100 μM, 3 h)[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

COX-1-IN-1 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: Vero
Concentration: 100 μM
Incubation Time: 3 h
Result: Revealed platelet and cell viabilities above 90%.
分子量

323.39

Formula

C20H21NO3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

COX-1-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

COX-1-IN-11369503-03-6COXCyclooxygenasecardiovascularneurologicalneurodegenerative diseaseplateletVeroInhibitorinhibitorinhibit

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产品名称：
COX-1-IN-1
目录号：
HY-162167
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