2. Membrane Transporter/Ion Channel Immunology/Inflammation Apoptosis
  3. CRM1 COX c-Myc Survivin
  4. LFS-1107

LFS-1107 是一种可逆的 CRM1 抑制剂 (Kd: 12.5 pM)。LFS-1107 可选择性清除 ENKTL 细胞并用于肿瘤研究。

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LFS-1107 Chemical Structure

LFS-1107 Chemical Structure

CAS No. : 1799330-91-8

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LFS-1107 相关抗体

Top Publications Citing Use of Products

查看 COX 亚型特异性产品:

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COX COX-1 COX-2 COX-3

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

LFS-1107 is a reversible CRM1 inhibitor (Kd: 12.5 pM). LFS-1107 can selectively eliminate extranodal natural killer/T cell lymphoma (ENKTL) cells and can be used for cancer research[1].

IC50 & Target

COX-2

 

体外研究
(In Vitro)

LFS-1107 (4-9 μM, 72 h) 可选择性清除 ENKT L细胞，同时保留正常人 PBMC ，且在 PBMC 细胞系中具有良好的安全性[1]。
LFS-1107 (0.15-500 μM, 24 h) 对人血小板几乎没有影响[1]。
LFS-1107 (50-200 nM, 3 h) 可在 293T 细胞中聚集 IκBα[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

LFS-1107 相关抗体:

Cell Viability Assay[1]

Cell Line: SNK6, HANK-1
Concentration: 0-800 nM
Incubation Time: 72 h
Result: Achieved IC50 value of 26 nM in SNK6 cell line and 36 nM in HANK-1 cell line.

Western Blot Analysis[1]

Cell Line: SNK6
Concentration: 62.5 nM, 125 nM, 250 nM, 500 nM, 1000 nM
Incubation Time: 3 h
Result: Suppressed the expression of CRM1 in a dose-dependent manner.
Downregulated the expression of proinflammatory and proliferative proteins p65, COX-2, c-Myc, and Survivin in a dose dependent manner.

Immunofluorescence[1]

Cell Line: 293T cells
Concentration: 50 nM, 100 nM, 200 nM
Incubation Time: 3 h
Result: Could lead to nuclear accumulation of IκBα in a dose dependent manner.
体内研究
(In Vivo)

LFS-1107 (10 mg/kg，腹腔注射，每周1次) 可改善异种移植 SNK6 细胞的小鼠模型的 ENKTL 症状[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SNK6 cell xenograft mouse model[1]
Dosage: 10 mg/kg
Administration: Intraperitoneal injection (i.p.), once a week
Result: Extended mouse survival and Eliminated tumor cells.
分子量

305.38

Formula

C12H11N5OS2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

LFS-1107 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LFS-11071799330-91-8LFS1107LFS 1107CRM1COXc-MycSurvivinChromosomal Maintenance 1Exportin 1XPO1CyclooxygenaseMycSNK6HANK-1293THelaXenograft mouse modelInhibitorENKTLinhibitorinhibit

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目录号：
HY-157136
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