2. Immunology/Inflammation
  3. COX
  4. Flunixin

Flunixin  (Synonyms: 氟尼克辛; Sch 14714)

目录号: HY-121046
产品使用指南

摩尔计算器

Flunixin 是一种环氧化酶 (COX) 抑制剂，对 COX-1 和 COX-2 的 IC50 值分别为 0.55 和 3.24 μM，其具有抗炎作用。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Flunixin Chemical Structure

Flunixin Chemical Structure

CAS No. : 38677-85-9

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Flunixin 的其他形式现货产品:

Customer Review

Other Forms of Flunixin:

Flunixin 相关抗体

Top Publications Citing Use of Products

查看 COX 亚型特异性产品:

查看所有亚型
COX COX-1 COX-2 COX-3

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Flunixin is a cyclooxygenase (COX) inhibitor with IC50 values of 0.55 and 3.24 μM for COX-1 and COX-2, respectively. Flunixin shows anti-inflammatory effects[1][2].

IC50 & Target[2]

COX-1

0.55 μM (IC50)

COX-2

3.24 μM (IC50)

体外研究
(In Vitro)

flunixin meglumine (10-1000 μM, 2 h) inhibits lipopolysaccharide (LPS)-induced activity of inducible nitric oxide synthase (iNOS) in RAW 264.7 murine macrophages[2].
flunixin meglumine (10-1000 μM, 2 h) inhibits lipopolysaccharide-induced activation of nuclear factor kappa B (NfκB) in RAW 264.7 murine macrophages[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Flunixin 相关抗体:

Cell Viability Assay[2]

Cell Line: RAW 264.7 murine macrophages
Concentration: 10, 100, 300, and 1000 μM
Incubation Time: 2 hours
Result: Inhibited LPS-induced nitric oxide release at concentrations between 100 and 1,000 µM (P=0.01).
体内研究
(In Vivo)

Flunixin meglumine (intravenous injection; 1.1 mg/kg; once) treatment inhibits the formation of exudate PGE2 and serum TXB2[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male sheep injected with Carrageenan[1]
Dosage: 1.1 mg/kg
Administration: Intravenous injection; 1.1 mg/kg; once
Result: Inhibited Carrageenan-induced exudate PGE2 formation (Emax, 100%, IC50, <0.4 nM) and serum TXB2 generation (Emax, 100%, IC50, 17 nM) for up to 32 h.
分子量

296.24

Formula

C14H11F3N2O2
CAS 号
中文名称

氟尼克辛
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Flunixin 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Flunixin38677-85-9Sch 14714氟尼克辛Sch14714Sch-14714COXCyclooxygenaseanti-inflammatory effectRAW 264.7 murine macrophagesInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Flunixin
目录号：
HY-121046
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z