2. GPCR/G Protein
  3. CRFR
  4. CP 154526

CP 154526 是一种强效、可透过血脑屏障的和选择性促皮质素释放因子受体 1 (CRF1) 拮抗剂，Ki 为 2.7 nM。CP 154526 对 CRF1 的选择性优于 CRF2 (Ki = >10 μM)。CP 154526 具有抗焦虑活性。

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CP 154526 Chemical Structure

CP 154526 Chemical Structure

CAS No. : 157286-86-7

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规格 是否有货
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CP 154526 的其他形式现货产品:

Customer Review

Other Forms of CP 154526:

CP 154526 相关抗体

Top Publications Citing Use of Products

查看 CRFR 亚型特异性产品:

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CRFR1 CRFR2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CP 154526 is a potent, brain-penetrant and selective corticotropin-releasing factor receptor 1 (CRF1) antagonist with a Ki of 2.7 nM. CP 154526 shows selective for CRF1 over CRF2 (Ki = >10 μM). CP 154526 has anxiolytic activities[1][2].

体外研究
(In Vitro)

CP 154526 可取代大鼠海马 CRF 受体 (IC50 = 0.5 nM) 和垂体 CRF 受体 (IC50 = 0.04 nM) 中的 [125I][Tyr0]CRF[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CP 154526 相关抗体:
体内研究
(In Vivo)

CP 154526 (1-10 mg/kg；腹腔注射；一次) 在大鼠高架十字迷宫测试中表现出抗焦虑样活性迹象[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague Dawley rats[2]
Dosage: 1 mg/kg, 3 mg/kg, 10 mg/kg
Administration: i.p.; once
Result: Exhibited signs of anxiolytic-like activity.
分子量

364.53

Formula

C23H32N4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CP 154526 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CP 154526157286-86-7CP154526CP-154526CRFRCorticotropin-releasing Factor ReceptorCRHRCRF1 antagonistanxiolytic activitiesbrain-penetrantInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-12130
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