CRISP3 - cysteine rich secretory protein 3 Gene

中文名称：富半胱氨酸的分泌蛋白 3

种属: Homo sapiens

同用名: Aeg2; CRS3; SGP28; CRISP-3; dJ442L6.3

关于 CRISP3

功能概要

该基因编码 CRISP、抗原 5 和发病机制相关蛋白 1 超家族中富含半胱氨酸的分泌蛋白 (CRISP) 家族的成员。编码的蛋白质具有一个 N 端 CRISP、抗原 5 和发病机制相关 1 蛋白结构域、一个铰链区和一个 C 端离子通道调节结构域。该蛋白质包含位于 N 端和 C 端结构域的半胱氨酸残基，形成八个二硫键，这是该家族的一个显着特征。该基因在男性生殖道中表达，在精子功能和受精中发挥作用，在女性生殖道中表达，在子宫内膜对胚胎植入的接受性中发挥作用。该基因在某些类型的前列腺癌中被上调。可变剪接导致多个转录本变体。[RefSeq 提供，2016 年 11 月]

This gene encodes a member of the cysteine-rich secretory protein (CRISP) family within the CRISP, antigen 5 and pathogenesis-related 1 proteins superfamily. The encoded protein has an N-terminal CRISP, antigen 5 and pathogenesis-related 1 proteins domain, a hinge region, and a C-terminal ion channel regulator domain. This protein contains cysteine residues, located in both the N- and C-terminal domains, that form eight disulfide bonds, a distinguishing characteristic of this family. This gene is expressed in the male reproductive tract where it plays a role in sperm function and fertilization, and the female reproductive tract where it plays a role in endometrial receptivity for embryo implantation. This gene is upregulated in certain types of prostate Cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016]