2. Gene
  3. Acaca - acetyl-Coenzyme A carboxylase alpha Gene

Acaca - acetyl-Coenzyme A carboxylase alpha Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：乙酰辅酶 A 羧化酶 α

种属: Mus musculus

同用名: Acac; Acc1; Gm738; A530025K05Rik

基因 ID: 107476 | 基因类型: protein coding

关于 Acaca

Chromosome 11: 84,020,498-84,292,477 forward strand.GRCm39:CM001004.3

This gene has 9 transcripts (splice variants), 205 orthologues, 4 paralogues and is associated with 5 phenotypes. Broad expression in mammary gland adult (RPKM 81.6), subcutaneous fat pad adult (RPKM 79.2) and 17 other tissues.

功能概要

该基因编码的蛋白可启动乙酰辅酶 A 羧化酶活性。参与乙酰辅酶A代谢过程；脂肪酸生物合成过程；和蛋白质同源四聚化。作用于多个过程的上游或内部，包括对前列腺素 E 刺激的细胞反应；脂质体内平衡；和组织稳态。位于胞质溶胶中。以多种结构表达，包括消化系统；外皮系统；神经系统;呼吸系统;和感觉器官。与人类 ACACA（乙酰辅酶 A 羧化酶 α）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables Acetyl-CoA Carboxylase activity. Involved in acetyl-CoA metabolic process; fatty acid biosynthetic process; and protein homotetramerization. Acts upstream of or within several processes, including cellular response to prostaglandin E stimulus; lipid homeostasis; and tissue homeostasis. Located in cytosol. Is expressed in several structures, including alimentary system; integumental system; nervous system; respiratory system; and sensory organ. Orthologous to human ACACA (Acetyl-CoA Carboxylase alpha). [provided by Alliance of Genome Resources, Apr 2022]

Acaca 基因产物(1)

mRNA Protein Name
NM_133360.3 NP_579938.2 acetyl-CoA carboxylase 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables acetyl-CoA carboxylase activity IDA
IDA: 通过直接分析推断
20952656 MGI
enables acetyl-CoA carboxylase activity IGI
IGI: 通过遗传相互作用推断
17210641 MGI
enables acetyl-CoA carboxylase activity IMP
IMP: 通过突变表型推断
8954960 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
20457939 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in acetyl-CoA metabolic process IDA
IDA: 通过直接分析推断
20952656 MGI
acts upstream of or within cellular response to prostaglandin E stimulus IDA
IDA: 通过直接分析推断
23479225 MGI
involved in fatty acid biosynthetic process IDA
IDA: 通过直接分析推断
20952656 MGI
involved in lipid biosynthetic process IGI
IGI: 通过遗传相互作用推断
17210641 MGI
involved in lipid biosynthetic process IMP
IMP: 通过突变表型推断
16717184 MGI
acts upstream of or within lipid homeostasis IMP
IMP: 通过突变表型推断
17210641 MGI
acts upstream of or within lipid metabolic process IMP
IMP: 通过突变表型推断
17210641 MGI
involved in protein homotetramerization IDA
IDA: 通过直接分析推断
20952656 MGI
acts upstream of or within protein metabolic process IMP
IMP: 通过突变表型推断
17210641 MGI
acts upstream of or within tissue homeostasis IMP
IMP: 通过突变表型推断
17210641 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in cytosol IDA
IDA: 通过直接分析推断
16717184 MGI
located in cytosol IDA
IDA: 通过直接分析推断
20952656 MGI
is active in cytosol IGI
IGI: 通过遗传相互作用推断
17210641 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Acaca 蛋白结构

AccC

AccC: COG0439 (116 - 618)

AccB

AccB: cl33922 (669 - 816)

Biotin_lipoyl

Biotin_lipoyl: pfam00364 (751 - 816)

ACC_central

ACC_central: pfam08326 (818 - 1567)

Carboxyl_trans

Carboxyl_trans: pfam01039 (1667 - 2215)

  • 0
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  • 800
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  • 1600
  • 2000
  • 2345 a.a.
蛋白主名 其他名称

acetyl-CoA carboxylase 1

ACC-alpha

acetyl-CoA carboxylase 265

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00119 ACACA Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS00120 Acaca Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS00121 Acaca Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Acaca NCBI NCBI:31
Macaca fascicularis Acaca NCBI NCBI:102138812
Macaca mulatta Acaca NCBI NCBI:714218
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