2. Gene
  3. CCR9 - C-C motif chemokine receptor 9 Gene

CCR9 - C-C motif chemokine receptor 9 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：CC 基序趋化因子受体 9

种属: Homo sapiens

同用名: GPR28; CDw199; GPR-9-6; CC-CKR-9

基因 ID: 10803 | 基因类型: protein coding

关于 CCR9

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:45,886,064-45,903,174 (from NCBI)

This gene has 4 transcripts (splice variants), 265 orthologues and 23 paralogues. Biased expression in small intestine (RPKM 2.0), duodenum (RPKM 1.6) and 6 other tissues.

功能概要

该基因编码的蛋白质是一种 G 蛋白偶联受体，具有七个跨膜结构域，属于 β 趋化因子受体家族。趋化因子及其受体是正常和炎症条件下胸腺细胞迁移和成熟的关键调节因子。该基因在小肠和结肠的 T 淋巴细胞中差异表达，其与趋化因子 25 的相互作用有助于小肠上皮内淋巴细胞归巢。这表明该基因在指导对胃肠道不同部分的免疫反应中的作用。该基因及其专属配体趋化因子 25 在多种恶性肿瘤中过表达，与肿瘤增殖、凋亡、侵袭、迁移和耐药密切相关。该基因映射到趋化因子受体基因簇。已发现该基因编码不同异构体的多个转录变体。[RefSeq 提供，2020 年 8 月]

The protein encoded by this gene is a G protein-coupled receptor with seven transmembrane domains that belongs to the beta Chemokine Receptor family. Chemokines and their receptors are key regulators of thymocyte migration and maturation in normal and inflammation conditions. This gene is differentially expressed in T lymphocytes of the small intestine and colon, and its interaction with chemokine 25 contributes to intestinal intra-epithelial lymphocyte homing to the small intestine. This suggests a role for this gene in directing immune responses to different segments of the gastrointestinal tract. This gene and its exclusive ligand, chemokine 25, are overexpressed in a variety of malignant tumors and are closely associated with tumor proliferation, Apoptosis, invasion, migration and drug resistance. This gene maps to the Chemokine Receptor gene cluster. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2020]

CCR9 基因产物(5)

mRNA Protein Name
NM_001386447.1 NP_001373376.1 C-C chemokine receptor type 9 isoform A
NM_006641.4 NP_006632.2 C-C chemokine receptor type 9 isoform B
NM_031200.3 NP_112477.1 C-C chemokine receptor type 9 isoform A
NM_001256369.2 NP_001243298.1 C-C chemokine receptor type 9 isoform B
NM_001386448.1 NP_001373377.1 C-C chemokine receptor type 9 isoform A
基因本体论
  • 细胞组分
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell surface IDA
IDA: 通过直接分析推断
18308860 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CCR9 蛋白结构

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (65 - 317)

  • 0
  • 100
  • 200
  • 300
  • 369 a.a.
蛋白主名 其他名称

C-C chemokine receptor type 9

G protein-coupled receptor 28

chemokine (C-C motif) receptor 9

重组 CCR9 蛋白

目录号 产品名 蛋白编号 纯度
HY-P700544 CCR9 Protein, Human (GST) P51686-1 (M1-S48) ≥95%

关联疾病

疾病名称 别名
Leukemia, Acute Lymphoblastic

Acute Lymphoblastic Leukemia

ALL

Acute Lymphocytic Leukemia

Leukemia, Acute Lymphocytic, Susceptibility To, 1

Acute Lymphoblastic Leukaemia

Precursor Lymphoblastic Lymphoma/Leukemia

Precursor Lymphoid Neoplasm

Leukemia, Acute Lymphoblastic, Susceptibility To

B-Cell Acute Lymphoblastic Leukemia

Leukemia, Acute Lymphocytic 1

Acute Lymphocytic Leukaemia

Acute Lymphoblastic Leukemia/Lymphoma

All1

Childhood Acute Lymphoblastic Leukemia

Leukemia Acute Lymphoblastic 1

Leukemia Acute Lymphoblastic B-Hyperdiploid

Leukemia Acute Lymphocytic

Leukemia Acute Lymphocytic 1

Leukemia B-Cell Acute Lymphoblastic

Leukemia T-Cell Acute Lymphoblastic

Leukemia, Acute Lymphoblastic, 3

ALL3

Lymphoblastic Leukemia Acute

Leukemia, Acute, Lymphoblastic

Precursor Cell Lymphoblastic Leukemia Lymphoma

Leukemia, Lymphocytic, Acute, L1

Leukemia, Acute Lymphoblastic, Susceptibility To, 3
Ascending Cholangitis
Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory
Ileitis

Crohn'S Ileitis
Cholangitis, Primary Sclerosing

Primary Sclerosing Cholangitis

PSC

Sclerosing Cholangitis

Cholangitis, Sclerosing

Cholangitis Primary Sclerosing

Psc - [Primary Sclerosing Cholangitis]
Celiac Disease 1

Celiac Disease

Coeliac Disease

Celiac Sprue

Celiac Disease, Susceptibility To

Gluten-Sensitive Enteropathy

Nontropical Sprue

Sprue

CELIAC1

Celiac Disease, Susceptibility To, 1

Celiac Sprue 1

Celiac Sprue, Susceptibility To, 1

Gluten-Sensitive Enteropathy 1

Gluten-Sensitive Enteropathy, Susceptibility To, 1

Idiopathic Steatorrhea

Cœliac Disease

Gluten Intolerance

Gluten-Induced Enteropathy

Gluten Enteropathy

Celiac Disease, Susceptibility To, Type 1

Childhood Celiac Disease

Coeliac Rickets

Gee Disease

Gee-Herter Disease

Heubner-Herter Disease

Idiopathic Steatorrhoea

Thaysen'S Disease

Herter Gee Syndrome
Immunodeficiency 49

IMD49

Severe Combined Immunodeficiency, T Cell-Negative, B Cell-Positive, Nk Cell-Positive, With Intellectual Disability, Spasticity, And Craniofacial Abnormalities

Scid, T Cell-Negative, B Cell-Positive, Nk Cell-Positive, With Intellectual Disability, Spasticity, And Craniofacial Abnormalities

Immunodeficiency 49, Severe Combined

Scid, T-Cell Negative, B-Cell Positive, Nk Cell Positive, With Intellectual Disability, Spasticity, And Craniofacial Abnormalities

Severe Combined Immunodeficiency, T-Cell Negative, B-Cell Positive, Nk Cell Positive, With Intellectual Disability, Spasticity, And Craniofacial Abnormalities

Scid, T-Cell-Negative, B-Cell-Positive, Nk-Cell-Positive, With Intellectual Disability, Spasticity, And Craniofacial Abnormalities
Precursor T-Cell Acute Lymphoblastic Leukemia

T-All

Precursor T-Cell Acute Lymphoblastic Leukemia/Lymphoma

Precursor T-Cell Acute Lymphocytic Leukemia

Precursor T-Cell Acute Lymphocytic Leukemia/Lymphoma

Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

Adult T-Cell Lymphoma/Leukemia
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-15724 Vercirnon Antagonist 98.26% Phase 2
Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-15724A Vercirnon sodium Antagonist 99.13% 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus CCR9 MGD MGI:1341902
Macaca mulatta CCR9 VGNC VGNC:70742
Felis catus CCR9 VGNC VGNC:102024
Bos taurus CCR9 VGNC VGNC:26989
Canis familiaris CCR9 VGNC VGNC:38917
Rattus norvegicus CCR9 RGD RGD:628750
Others CCR9 NCBI
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