1. Gene
  2. CHRNA5 - cholinergic receptor nicotinic alpha 5 subunit Gene

CHRNA5 - cholinergic receptor nicotinic alpha 5 subunit Gene

中文名称:胆碱能受体烟碱α5 亚单位

种属: Homo sapiens

同用名: LNCR2

基因 ID: 1138 | 基因类型: protein coding

关于 CHRNA5

Cytogenetic location: 15q25.1 Genomic coordinates (GRCh38): 15:78,565,520-78,595,269 (from NCBI)

This gene has 4 transcripts (splice variants), 199 orthologues, 45 paralogues and is associated with 1 phenotype. Broad expression in gall bladder (RPKM 1.4), colon (RPKM 1.2) and 19 other tissues.

功能概要

由该基因编码的蛋白质是烟碱型乙酰胆碱受体亚基,是介导突触快速信号传输的配体门控离子通道超家族的成员。这些受体被认为是由独立但相似的亚基组成的异五聚体。该基因的缺陷与 2 型肺癌 (LNCR2) 的易感性有关。[RefSeq 提供,2010 年 6 月]

The protein encoded by this gene is a nicotinic acetylcholine receptor subunit and a member of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. These receptors are thought to be heteropentamers composed of separate but similar subunits. Defects in this gene have been linked to susceptibility to lung Cancer type 2 (LNCR2).[provided by RefSeq, Jun 2010]

CHRNA5 基因产物(7)

mRNA Protein Name
NM_000745.4 NP_000736.2 neuronal acetylcholine receptor subunit alpha-5 isoform 1 precursor
NM_001307945.2 NP_001294874.1 neuronal acetylcholine receptor subunit alpha-5 isoform 2 precursor
NM_001395171.1 NP_001382100.1 neuronal acetylcholine receptor subunit alpha-5 isoform 3 precursor
NM_001395172.1 NP_001382101.1 neuronal acetylcholine receptor subunit alpha-5 isoform 4 precursor
NM_001395173.1 NP_001382102.1 neuronal acetylcholine receptor subunit alpha-5 isoform 5 precursor
NM_001395174.1 NP_001382103.1 neuronal acetylcholine receptor subunit alpha-5 isoform 6 precursor
NM_001395175.1 NP_001382104.1 neuronal acetylcholine receptor subunit alpha-5 isoform 7 precursor
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables acetylcholine receptor activity IDA
IDA: 通过直接分析推断
1542648 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
8663494 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in behavioral response to nicotine IMP
IMP: 通过突变表型推断
18227835 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

CHRNA5 蛋白结构

Neur_chan_LBD

Neur_chan_LBD: Neurotransmitter-gated ion-channel ligand binding domain (47 - 249)

Neur_chan_memb

Neur_chan_memb: Neurotransmitter-gated ion-channel transmembrane region (257 - 380)

Neur_chan_memb

Neur_chan_memb: Neurotransmitter-gated ion-channel transmembrane region (376 - 447)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 468 a.a.
蛋白主名 其他名称

neuronal acetylcholine receptor subunit alpha-5

Cholinergic receptor, neuronal nicotinic, alpha polypeptide-5

CHRNA5 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
CHRNA5 P30532 CHRNB2 Homo sapiens P17787
Anti Tag CoIP
8663494
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 CHRNA5 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70340 nAChRα5 Protein, Human (HEK293, His) P30532/NP_000736.2 (R23-T254) ≥95%

关联疾病

疾病名称 别名
Smoking As A Quantitative Trait Locus 3

Lung Cancer Susceptibility 2

Nicotine Dependence

SQTL3

Nicotine Dependence, Susceptibility To

Tobacco Addiction

Nicotine Dependence

Tobacco Addiction, Susceptibility To

Nicotine Addiction

Tobacco Use Disorder

Smoking Habit

Nicotine Dependence, Protection Against

Nicotine Addiction, Protection From

Cigarette Habituation

Cigarette Habituation, Susceptibility To

Smoking Habit, Susceptibility To

Nicotine Dependence, Susceptibility To

Nicotine Addiction, Susceptibility To

Addiction, Tobacco, Susceptibility To

Compulsive Tobacco User Syndrome

Tobacco Dependence

Tobacco Dependence Syndrome

Cigarette Addiction

Cigarette Dependence

Smoking Addiction

Smokers Syndrome

Substance Dependence
Cocaine Dependence
Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma

Drug Dependence
Autosomal Dominant Nocturnal Frontal Lobe Epilepsy

Adnfle

Autosomal Dominant Sleep-Related Hypermotor Epilepsy

Enfl

Benign Familial Infantile Seizures 6

Benign Familial Infantile Seizures, 6

Nocturnal Frontal Lobe Epilepsy-4

Enfl1

Epilepsy, Nocturnal Frontal Lobe, 1

Epilepsy, Nocturnal Frontal Lobe, Type 1

Schizophrenia 19

SCZD19

Schizophrenia 19 With Or Without An Affective Disorder

Schizophrenia 19, Susceptibility To

{Schizophrenia 19, Susceptibility To}

Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1

Alcohol Dependence

Alcoholism

Alcohol Dependence, Susceptibility To

Alcohol Dependence, Protection Against

Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against

Alcoholism, Susceptibility To

Alcoholic Intoxication, Chronic

Pharyngeal Neoplasms

Chronic Alcoholism

Dipsomania

Alcohol Addiction

Ethanol Dependence

Chronic Ethanolism

Chronic Alcoholic Disease Nos

Alcoholic Disease Nos

Alcoholic

Attention Deficit-Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder

ADHD

Attention Deficit Disorder

Attention Deficit-Hyperactivity Disorder, Susceptibility To

Attention Deficit Disorder With Hyperactivity

Hyperkinetic Disorder

Hyperactivity Of Childhood

Attention-Deficit/Hyperactivity Disorder

Add

Addh

Attention Deficit

Attention Deficit Disorder Of Childhood With Hyperactivity

Attention Deficit Disorder With Hyperactivity Syndrome

Hyperkinetic Syndrome

Attention-Deficit Hyperactivity Disorder

Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type

Disturbance Of Activity And Attention

Disorder Of Activity And Attention

Adhd - [Attention Deficit Hyperactivity Disorder]

Hyperkinetic Disorders

Disorder Of Activity And Attention With Hyperkinesia

Attention Deficit Syndrome With Hyperactivity

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus CHRNA5 MGD MGI:87889
Canis familiaris CHRNA5 VGNC VGNC:49739
Rattus norvegicus CHRNA5 RGD RGD:2347
Macaca mulatta CHRNA5 VGNC VGNC:71048
Felis catus CHRNA5 VGNC VGNC:60882
Bos taurus CHRNA5 VGNC VGNC:27327
Others CHRNA5 NCBI