2. Gene
  3. Becn1 - beclin 1 Gene

Becn1 - beclin 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：beclin 1

种属: Rattus norvegicus

同用名: Beclin1

基因 ID: 114558 | 基因类型: protein coding

关于 Becn1

Primary_assembly 10: 86,231,388-86,246,742 reverse strand.mRatBN7.2:CM026983.1

This gene has 3 transcripts (splice variants), 214 orthologues, 1 paralogue and is associated with 63 phenotypes. Biased expression in Kidney (RPKM 276.8), Thymus (RPKM 266.7) and 9 other tissues.

功能概要

该基因编码的蛋白可启动泛素蛋白连接酶结合活性。参与多个过程，包括细胞对金属离子的反应；细胞凋亡过程的调节；和液泡组织的调节。位于细胞质中；树突;和核。与跨高尔基网络共定位。用于研究脑缺血和大脑中动脉梗塞。多种疾病的生物标志物，包括 Barrett 食管；急性坏死性胰腺炎;动脉疾病（多发性）；脑部疾病（多种）；和神经病（多种）。该基因的人类直系同源物与马查多-约瑟夫病有关。与人类 BECN1 (beclin 1) 同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables ubiquitin protein Ligase binding activity. Involved in several processes, including cellular response to metal ion; regulation of apoptotic process; and regulation of vacuole organization. Located in cytoplasm; dendrite; and nucleus. Colocalizes with trans-Golgi network. Used to study brain ischemia and middle cerebral artery infarction. Biomarker of several diseases, including Barrett's esophagus; acute necrotizing pancreatitis; artery disease (multiple); brain disease (multiple); and neuropathy (multiple). Human ortholog(s) of this gene implicated in Machado-Joseph disease. Orthologous to human BECN1 (beclin 1). [provided by Alliance of Genome Resources, Apr 2022]

Becn1 基因产物(4)

mRNA Protein Name
NM_053739.2 NP_446191.1 beclin-1
NM_001034117.1 NP_001029289.1 beclin-1
NM_001034117.1 NP_001029289.1 beclin-1
NM_053739.2 NP_446191.1 beclin-1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
25117440 RGD
enables ubiquitin protein ligase binding IPI
IPI: 通过物理相互作用推断
24879156 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in JNK cascade IMP
IMP: 通过突变表型推断
27769861 RGD
involved in SMAD protein signal transduction IDA
IDA: 通过直接分析推断
27769861 RGD
involved in autophagosome assembly IMP
IMP: 通过突变表型推断
16420522 RGD
involved in autophagy IMP
IMP: 通过突变表型推断
16697404 RGD
involved in cellular response to aluminum ion IEP
IEP: 通过表达模式推断
22138567 RGD
involved in cellular response to amino acid starvation IEP
IEP: 通过表达模式推断
22835012 RGD
involved in cellular response to copper ion IEP
IEP: 通过表达模式推断
22540380 RGD
involved in cellular response to epidermal growth factor stimulus IEP
IEP: 通过表达模式推断
20539009 RGD
involved in cellular response to hydrogen peroxide IEP
IEP: 通过表达模式推断
23314838 RGD
involved in cellular response to oxygen-glucose deprivation IEP
IEP: 通过表达模式推断
27769861 RGD
involved in negative regulation of apoptotic process IMP
IMP: 通过突变表型推断
20075199 RGD
involved in negative regulation of lysosome organization IMP
IMP: 通过突变表型推断
25561470 RGD
involved in p38MAPK cascade IMP
IMP: 通过突变表型推断
27769861 RGD
involved in positive regulation of autophagosome assembly IMP
IMP: 通过突变表型推断
25561470 RGD
involved in positive regulation of autophagy IMP
IMP: 通过突变表型推断
21490676 RGD
involved in positive regulation of intrinsic apoptotic signaling pathway IMP
IMP: 通过突变表型推断
27031958 RGD
involved in positive regulation of stress granule assembly IMP
IMP: 通过突变表型推断
30404558 RGD
involved in response to hypoxia IEP
IEP: 通过表达模式推断
22449108 RGD
involved in response to iron(II) ion IEP
IEP: 通过表达模式推断
23187302 RGD
involved in response to lead ion IEP
IEP: 通过表达模式推断
22927075 RGD
involved in response to nutrient levels IEP
IEP: 通过表达模式推断
17665967 RGD
involved in response to vitamin E IEP
IEP: 通过表达模式推断
19138675 RGD
involved in response to xenobiotic stimulus IEP
IEP: 通过表达模式推断
22521819 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in dendrite IDA
IDA: 通过直接分析推断
21490676 RGD
located in trans-Golgi network IDA
IDA: 通过直接分析推断
11306555 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Becn1 蛋白结构

BH3

BH3: pfam15285 (104 - 126)

APG6_N

APG6_N: pfam17675 (132 - 258)

APG6

APG6: pfam04111 (264 - 442)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 448 a.a.
蛋白主名 其他名称

beclin-1

beclin 1 (coiled-coil, myosin-like BCL2-interacting protein)

beclin 1, autophagy related

coiled-coil myosin-like BCL2-interacting protein

相关产品

Pre-clinical Phase
生物活性分子 (6)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-137506 XST-14 99.26% 否
HY-149954 SARS-CoV-2-IN-39 Inhibitor 99.51% 否
HY-167843 Alborixin Inhibitor / 否
HY-RS01463 BECN1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS01464 Becn1 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS01465 Becn1 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Becn1 NCBI NCBI:8678
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