2. Gene
  3. Bmp4 - bone morphogenetic protein 4 Gene

Bmp4 - bone morphogenetic protein 4 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Bmp-4; Bmp2b; Bmp2b1; Bmp2b-1

基因 ID: 12159 | 基因类型: protein coding

关于 Bmp4

功能概要

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of Smad Family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates heart development and adipogenesis. Homozygous knockout mice die in utero, while a conditional knockout mouse exhibits defects in heart development. Transgenic mice overexpressing this gene in a neuron-specific manner exhibit a phenotype resembling the rare hereditary connective tissue disease, fibrodysplasia ossificans progressiva. [provided by RefSeq, Jul 2016]

Bmp4 基因产物(2)

mRNA Protein Name
NM_001316360.1 NP_001303289.1 bone morphogenetic protein 4 preproprotein
NM_007554.3 NP_031580.2 bone morphogenetic protein 4 preproprotein
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables heparin binding IDA
IDA: 通过直接分析推断
15381701 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
12897139 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within BMP signaling pathway IDA
IDA: 通过直接分析推断
14623234 MGI
acts upstream of or within BMP signaling pathway IGI
IGI: 通过遗传相互作用推断
15975920 MGI
involved in BMP signaling pathway IMP
IMP: 通过突变表型推断
15070745 MGI
acts upstream of ameloblast differentiation IDA
IDA: 通过直接分析推断
15525533 MGI
acts upstream of or within anatomical structure development IGI
IGI: 通过遗传相互作用推断
14681194 MGI
acts upstream of or within anatomical structure formation involved in morphogenesis IGI
IGI: 通过遗传相互作用推断
16916379 MGI
acts upstream of or within angiogenesis IMP
IMP: 通过突变表型推断
15070745 MGI
acts upstream of or within anterior/posterior axis specification IGI
IGI: 通过遗传相互作用推断
10964473 MGI
involved in aortic valve morphogenesis IMP
IMP: 通过突变表型推断
15070745 MGI
NOT involved in apoptotic process involved in endocardial cushion morphogenesis IMP
IMP: 通过突变表型推断
18924235 MGI
acts upstream of or within blood vessel development IDA
IDA: 通过直接分析推断
17881493 MGI
acts upstream of or within bone development IDA
IDA: 通过直接分析推断
8358941 MGI
acts upstream of or within branching involved in prostate gland morphogenesis IMP
IMP: 通过突变表型推断
11401393 MGI
acts upstream of or within branching involved in ureteric bud morphogenesis IGI
IGI: 通过遗传相互作用推断
17522159 MGI
acts upstream of or within bud elongation involved in lung branching IDA
IDA: 通过直接分析推断
18367557 MGI
acts upstream of or within camera-type eye development IGI
IGI: 通过遗传相互作用推断
14681194 MGI
acts upstream of or within camera-type eye development IMP
IMP: 通过突变表型推断
9268572 MGI
acts upstream of or within camera-type eye morphogenesis IMP
IMP: 通过突变表型推断
9268572 MGI
NOT involved in cardiac jelly development IMP
IMP: 通过突变表型推断
18924235 MGI
involved in cardiac muscle cell differentiation IGI
IGI: 通过遗传相互作用推断
21145505 MGI
NOT involved in cardiac right ventricle morphogenesis IMP
IMP: 通过突变表型推断
18924235 MGI
acts upstream of or within cell fate commitment IDA
IDA: 通过直接分析推断
12421925 MGI
acts upstream of cell population proliferation IGI
IGI: 通过遗传相互作用推断
18028901 MGI
acts upstream of or within cellular response to growth factor stimulus IDA
IDA: 通过直接分析推断
7848824 MGI
acts upstream of chondrocyte differentiation IDA
IDA: 通过直接分析推断
17481601 MGI
involved in chondrocyte differentiation IMP
IMP: 通过突变表型推断
20059955 MGI
involved in coronary vasculature development IMP
IMP: 通过突变表型推断
15070745 MGI
acts upstream of or within cranial suture morphogenesis IDA
IDA: 通过直接分析推断
9477322 MGI
involved in deltoid tuberosity development IMP
IMP: 通过突变表型推断
20059955 MGI
acts upstream of or within dorsal/ventral neural tube patterning IDA
IDA: 通过直接分析推断
15218525 MGI
acts upstream of or within embryonic cranial skeleton morphogenesis IMP
IMP: 通过突变表型推断
9268572 MGI
acts upstream of or within embryonic digit morphogenesis IGI
IGI: 通过遗传相互作用推断
9268572 MGI
acts upstream of or within embryonic hindlimb morphogenesis IGI
IGI: 通过遗传相互作用推断
10964473 MGI
acts upstream of or within embryonic limb morphogenesis IGI
IGI: 通过遗传相互作用推断
9664686 MGI
acts upstream of or within embryonic limb morphogenesis IMP
IMP: 通过突变表型推断
9664686 MGI
acts upstream of or within embryonic morphogenesis IMP
IMP: 通过突变表型推断
15716346 MGI
acts upstream of or within embryonic skeletal joint morphogenesis IGI
IGI: 通过遗传相互作用推断
9664686 MGI
acts upstream of or within embryonic skeletal joint morphogenesis IMP
IMP: 通过突变表型推断
9664686 MGI
acts upstream of or within embryonic skeletal system development IMP
IMP: 通过突变表型推断
16712836 MGI
acts upstream of or within embryonic skeletal system morphogenesis IMP
IMP: 通过突变表型推断
16712836 MGI
involved in endocardial cushion development IMP
IMP: 通过突变表型推断
18924235 MGI
involved in endochondral ossification IMP
IMP: 通过突变表型推断
20059955 MGI
acts upstream of or within endoderm development IDA
IDA: 通过直接分析推断
24835669 MGI
acts upstream of epithelial cell proliferation IGI
IGI: 通过遗传相互作用推断
18028901 MGI
NOT involved in epithelial to mesenchymal transition involved in endocardial cushion formation IMP
IMP: 通过突变表型推断
18924235 MGI
acts upstream of or within epithelial-mesenchymal cell signaling IDA
IDA: 通过直接分析推断
8104708 MGI
acts upstream of or within epithelium development IDA
IDA: 通过直接分析推断
8898217 MGI
acts upstream of or within erythrocyte differentiation IDA
IDA: 通过直接分析推断
15591122 MGI
NOT involved in eye development IGI
IGI: 通过遗传相互作用推断
16154126 MGI
acts upstream of or within forebrain development IGI
IGI: 通过遗传相互作用推断
14681194 MGI
acts upstream of or within forebrain development IMP
IMP: 通过突变表型推断
9268572 MGI
involved in gene expression IDA
IDA: 通过直接分析推断
11784076 MGI
acts upstream of or within germ cell development IMP
IMP: 通过突变表型推断
15289457 MGI
involved in glomerular capillary formation IMP
IMP: 通过突变表型推断
18272846 MGI
acts upstream of or within heart development IMP
IMP: 通过突变表型推断
12975322 MGI
acts upstream of or within hematopoietic progenitor cell differentiation IDA
IDA: 通过直接分析推断
7799920 MGI
acts upstream of or within inner ear auditory receptor cell differentiation IGI
IGI: 通过遗传相互作用推断
17555714 MGI
involved in kidney development IGI
IGI: 通过遗传相互作用推断
16154126 MGI
acts upstream of or within kidney development IMP
IMP: 通过突变表型推断
9268572 MGI
acts upstream of or within lens induction in camera-type eye IMP
IMP: 通过突变表型推断
9851982 MGI
acts upstream of or within lung development IMP
IMP: 通过突变表型推断
16414041 MGI
acts upstream of or within mammary gland formation IMP
IMP: 通过突变表型推断
17071745 MGI
involved in membranous septum morphogenesis IMP
IMP: 通过突变表型推断
15070745 MGI
acts upstream of or within mesoderm formation IDA
IDA: 通过直接分析推断
7799920 MGI
acts upstream of or within mesodermal cell differentiation IDA
IDA: 通过直接分析推断
7799920 MGI
acts upstream of or within mesodermal cell fate determination IMP
IMP: 通过突变表型推断
7657163 MGI
acts upstream of or within metanephros development IDA
IDA: 通过直接分析推断
12631064 MGI
acts upstream of or within metanephros development IMP
IMP: 通过突变表型推断
12631064 MGI
NOT involved in muscular septum morphogenesis IMP
IMP: 通过突变表型推断
18924235 MGI
involved in negative regulation of branching involved in ureteric bud morphogenesis IDA
IDA: 通过直接分析推断
15634693 MGI
acts upstream of or within negative regulation of branching involved in ureteric bud morphogenesis IGI
IGI: 通过遗传相互作用推断
21281623 MGI
acts upstream of or within negative regulation of chondrocyte differentiation IDA
IDA: 通过直接分析推断
17481601 MGI
acts upstream of or within negative regulation of epithelial cell proliferation IGI
IGI: 通过遗传相互作用推断
18028901 MGI
acts upstream of or within negative regulation of epithelial cell proliferation IMP
IMP: 通过突变表型推断
11401393 MGI
involved in negative regulation of extrinsic apoptotic signaling pathway IMP
IMP: 通过突变表型推断
15070745 MGI
acts upstream of or within negative regulation of gene expression IDA
IDA: 通过直接分析推断
11493558 MGI
acts upstream of or within negative regulation of prostatic bud formation IDA
IDA: 通过直接分析推断
18393306 MGI
acts upstream of or within negative regulation of prostatic bud formation IMP
IMP: 通过突变表型推断
11401393 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
9585504 MGI
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
15070745 MGI
acts upstream of or within neural tube closure IDA
IDA: 通过直接分析推断
19850029 MGI
acts upstream of or within neuron fate commitment IDA
IDA: 通过直接分析推断
17698011 MGI
acts upstream of or within neuron fate commitment IMP
IMP: 通过突变表型推断
17698011 MGI
acts upstream of or within odontogenesis of dentin-containing tooth IDA
IDA: 通过直接分析推断
15525533 MGI
acts upstream of or within odontogenesis of dentin-containing tooth IGI
IGI: 通过遗传相互作用推断
16179481 MGI
acts upstream of or within organ induction IMP
IMP: 通过突变表型推断
9806931 MGI
acts upstream of or within osteoblast differentiation IDA
IDA: 通过直接分析推断
15381701 MGI
involved in outflow tract morphogenesis IGI
IGI: 通过遗传相互作用推断
21145505 MGI
involved in outflow tract septum morphogenesis IMP
IMP: 通过突变表型推断
15070745 MGI
acts upstream of or within pericyte cell differentiation IDA
IDA: 通过直接分析推断
16546160 MGI
involved in pharyngeal arch artery morphogenesis IMP
IMP: 通过突变表型推断
15070745 MGI
acts upstream of or within pituitary gland development IMP
IMP: 通过突变表型推断
9806931 MGI
involved in positive regulation of BMP signaling pathway IDA
IDA: 通过直接分析推断
20059955 MGI
acts upstream of or within positive regulation of ERK1 and ERK2 cascade IDA
IDA: 通过直接分析推断
18692041 MGI
involved in positive regulation of branching involved in lung morphogenesis IMP
IMP: 通过突变表型推断
17350185 MGI
involved in positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis IGI
IGI: 通过遗传相互作用推断
23863481 MGI
involved in positive regulation of cell migration IMP
IMP: 通过突变表型推断
24603907 MGI
acts upstream of or within positive regulation of cell population proliferation IMP
IMP: 通过突变表型推断
18692041 MGI
involved in positive regulation of cell population proliferation IMP
IMP: 通过突变表型推断
15070745 MGI
involved in positive regulation of endothelial cell differentiation IDA
IDA: 通过直接分析推断
20406889 MGI
involved in positive regulation of endothelial cell proliferation IDA
IDA: 通过直接分析推断
20406889 MGI
acts upstream of or within positive regulation of epithelial cell differentiation IDA
IDA: 通过直接分析推断
15525533 MGI
involved in positive regulation of epithelial to mesenchymal transition IGI
IGI: 通过遗传相互作用推断
23863481 MGI
involved in positive regulation of gene expression IDA
IDA: 通过直接分析推断
19001364 MGI
acts upstream of or within positive regulation of gene expression IMP
IMP: 通过突变表型推断
18622394 MGI
involved in positive regulation of miRNA transcription IGI
IGI: 通过遗传相互作用推断
21145505 MGI
acts upstream of or within positive regulation of neuron differentiation IDA
IDA: 通过直接分析推断
9786991 MGI
involved in positive regulation of odontoblast differentiation IMP
IMP: 通过突变表型推断
29148101 MGI
acts upstream of or within positive regulation of ossification IDA
IDA: 通过直接分析推断
8358941 MGI
acts upstream of positive effect positive regulation of protein localization to nucleus IMP
IMP: 通过突变表型推断
34995814 MGI
acts upstream of or within positive regulation of protein phosphorylation IMP
IMP: 通过突变表型推断
18692041 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
8104708 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
8898217 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
18692041 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
15070745 MGI
acts upstream of or within post-embryonic development IMP
IMP: 通过突变表型推断
9268572 MGI
acts upstream of or within prostate gland morphogenesis IMP
IMP: 通过突变表型推断
9268572 MGI
acts upstream of prostatic bud formation IMP
IMP: 通过突变表型推断
11401393 MGI
involved in pulmonary valve morphogenesis IMP
IMP: 通过突变表型推断
15070745 MGI
acts upstream of or within regulation of branching involved in prostate gland morphogenesis IMP
IMP: 通过突变表型推断
15772937 MGI
acts upstream of or within regulation of cartilage development IDA
IDA: 通过直接分析推断
20501701 MGI
acts upstream of or within regulation of cell differentiation IGI
IGI: 通过遗传相互作用推断
15525533 MGI
acts upstream of or within regulation of gene expression IDA
IDA: 通过直接分析推断
10704389 MGI
acts upstream of or within regulation of gene expression IMP
IMP: 通过突变表型推断
11436557 MGI
acts upstream of or within regulation of mesodermal cell differentiation IDA
IDA: 通过直接分析推断
17881493 MGI
acts upstream of or within regulation of mesodermal cell differentiation IGI
IGI: 通过遗传相互作用推断
17881493 MGI
acts upstream of or within regulation of morphogenesis of a branching structure IMP
IMP: 通过突变表型推断
11401393 MGI
acts upstream of or within regulation of odontogenesis of dentin-containing tooth IGI
IGI: 通过遗传相互作用推断
9244299 MGI
acts upstream of or within regulation of smooth muscle cell differentiation IDA
IDA: 通过直接分析推断
17881493 MGI
acts upstream of or within regulation of smooth muscle cell differentiation IGI
IGI: 通过遗传相互作用推断
17881493 MGI
acts upstream of or within regulation of smooth muscle cell proliferation IDA
IDA: 通过直接分析推断
15800000 MGI
acts upstream of or within renal system process IMP
IMP: 通过突变表型推断
9268572 MGI
acts upstream of or within skeletal system development IDA
IDA: 通过直接分析推断
14654219 MGI
acts upstream of or within skeletal system development IMP
IMP: 通过突变表型推断
15936012 MGI
acts upstream of or within smooth muscle cell differentiation IDA
IDA: 通过直接分析推断
16546160 MGI
involved in smooth muscle tissue development IMP
IMP: 通过突变表型推断
12631064 MGI
acts upstream of or within specification of animal organ position IMP
IMP: 通过突变表型推断
17071745 MGI
involved in specification of segmental identity, mandibular segment IDA
IDA: 通过直接分析推断
11784076 MGI
acts upstream of or within telencephalon regionalization IDA
IDA: 通过直接分析推断
16855091 MGI
acts upstream of or within telencephalon regionalization IGI
IGI: 通过遗传相互作用推断
11719201 MGI
involved in tendon cell differentiation IMP
IMP: 通过突变表型推断
20059955 MGI
acts upstream of or within trachea formation IMP
IMP: 通过突变表型推断
18692041 MGI
acts upstream of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
8898217 MGI
involved in ureter morphogenesis IMP
IMP: 通过突变表型推断
17442697 MGI
acts upstream of or within ureteric bud development IDA
IDA: 通过直接分析推断
12631064 MGI
acts upstream of or within ureteric bud development IMP
IMP: 通过突变表型推断
12631064 MGI
acts upstream of or within vasculature development IMP
IMP: 通过突变表型推断
17881493 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in extracellular region IDA
IDA: 通过直接分析推断
8358941 MGI
located in extracellular space IDA
IDA: 通过直接分析推断
17481601 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

bone morphogenetic protein 4

bone morphogenetic protein 2B

重组 Bmp4 蛋白

目录号 产品名 蛋白编号 纯度
HY-P74379 BMP-4 Protein, Mouse (HEK293, Fc) P21275 (S293-R408) ≥95%
HY-P700163AF Animal-Free BMP-4 Protein, Mouse (His) P21275 (K303-R408) ≥95%

相关产品

Pre-clinical Phase
生物活性分子 (6)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-124697 BMP signaling agonist sb4 Agonist 99.98% 否
HY-16712 LDN-214117 Inhibitor 99.92% 否
HY-18961 PD 407824 Inhibitor 98.34% 否
HY-147372 SJ000063181 Agonist 98.92% 否
HY-P10710 BMP-4 Inhibitor / 否
HY-RS01539 BMP4 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Bmp4 NCBI NCBI:652
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