2. Gene
  3. CMKLR1 - chemerin chemokine-like receptor 1 Gene

CMKLR1 - chemerin chemokine-like receptor 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：凯莫瑞趋化因子样受体 1

种属: Homo sapiens

同用名: DEZ; RVER1; ChemR23; CHEMERINR

基因 ID: 1240 | 基因类型: protein coding

关于 CMKLR1

Cytogenetic location: 12q23.3 Genomic coordinates (GRCh38): 12:108,288,046-108,339,311 (from NCBI)

This gene has 6 transcripts (splice variants), 333 orthologues and 8 paralogues. Broad expression in spleen (RPKM 14.3), placenta (RPKM 10.1) and 22 other tissues.

功能概要

启用脂肪动力学激素结合活性和脂肪动力学激素受体活性。涉及多个过程，包括 NF-kappaB 转录因子活性的负调节；巨噬细胞趋化性的正向调节；和调节钙介导的信号。位于质膜。 [由基因组资源联盟提供，2022 年 4 月]

Enables adipokinetic hormone binding activity and adipokinetic hormone receptor activity. Involved in several processes, including negative regulation of NF-kappaB transcription factor activity; positive regulation of macrophage chemotaxis; and regulation of calcium-mediated signaling. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

CMKLR1 基因产物(4)

mRNA Protein Name
NM_001142343.2 NP_001135815.1 chemerin-like receptor 1 isoform a
NM_001142344.2 NP_001135816.1 chemerin-like receptor 1 isoform a
NM_001142345.2 NP_001135817.1 chemerin-like receptor 1 isoform a
NM_004072.3 NP_004063.1 chemerin-like receptor 1 isoform b
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables adipokinetic hormone binding IDA
IDA: 通过直接分析推断
27716822 GOA
enables adipokinetic hormone receptor activity IDA
IDA: 通过直接分析推断
27716822 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
14530373 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in G protein-coupled receptor signaling pathway IDA
IDA: 通过直接分析推断
14530373 GOA
involved in chemotaxis IDA
IDA: 通过直接分析推断
14530373 GOA
involved in negative regulation of NF-kappaB transcription factor activity IDA
IDA: 通过直接分析推断
15753205 GOA
involved in positive regulation of macrophage chemotaxis IMP
IMP: 通过突变表型推断
19443732 GOA
involved in regulation of calcium-mediated signaling IDA
IDA: 通过直接分析推断
14530373 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in plasma membrane IDA
IDA: 通过直接分析推断
14530373 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

chemerin-like receptor 1

G-protein coupled receptor ChemR23

关联疾病

疾病名称 别名
Monckeberg Arteriosclerosis

Monckeberg Medial Calcific Sclerosis
Cardiovascular Syphilis

Syphilis, Cardiovascular
Hepatic Adenomas, Familial

Hepatic Adenoma, Somatic

Familial Hepatic Adenoma

Familial Liver Cell Adenomas

Liver Cell Adenomas, Familial

Hepatic Adenomas Familial

HEPAF

Ha

Hepatocellular Adenomas

Hepatocellular Adenoma
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-138097 α-NETA ≥98.0% 否
HY-P1844A Chemerin-9 (149-157) (TFA) 95.41% 否
HY-156460 CMKLR1 antagonist 1 99.44% 否
HY-P1844 Chemerin-9 (149-157) / 否
HY-RS02860 CMKLR1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus CMKLR1 VGNC VGNC:60999
Macaca mulatta CMKLR1 VGNC VGNC:99920
Bos taurus CMKLR1 VGNC VGNC:52753
Canis familiaris CMKLR1 VGNC VGNC:39378
Rattus norvegicus CMKLR1 RGD RGD:69359
Mus musculus CMKLR1 MGD MGI:109603
Others CMKLR1 NCBI
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