Comt - catechol-O-methyltransferase Gene

中文名称：儿茶酚-O-甲基转移酶

种属: Mus musculus

同用名: Comt1; D16Wsu103e; D330014B15Rik

关于 Comt

功能概要

该基因编码的蛋白可启动儿茶酚 O-甲基转移酶活性。在磷酸盐饥饿和多巴胺分解代谢过程的细胞反应的上游或细胞内起作用。位于线粒体中。以多种结构表达，包括消化系统；心血管系统;中枢神经系统;泌尿生殖系统；和感觉器官。用于研究认知障碍和先兆子痫。该基因的人类直系同源物与多种疾病有关，包括注意力缺陷多动障碍；皮肤和结缔组织的自身免疫性疾病（多种）；神经性贪食症;认知障碍（多种）；和生殖器官癌（多发性）。与人类 COMT（儿茶酚-O-甲基转移酶）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables catechol O-methyltransferase activity. Acts upstream of or within cellular response to phosphate starvation and dopamine catabolic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and sensory organ. Used to study cognitive disorder and pre-eclampsia. Human ortholog(s) of this gene implicated in several diseases, including attention deficit hyperactivity disorder; autoimmune disease of skin and connective tissue (multiple); bulimia nervosa; cognitive disorder (multiple); and reproductive organ Cancer (multiple). Orthologous to human COMT (catechol-O-methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]