2. Gene
  3. Fasl - Fas ligand (TNF superfamily, member 6) Gene

Fasl - Fas ligand (TNF superfamily, member 6) Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: gld; CD178; CD95L; Fas-L; Faslg; CD95-L; Tnfsf6; Tnlg1a; APT1LG1

基因 ID: 14103 | 基因类型: protein coding

关于 Fasl

功能概要

Predicted to enable death receptor binding activity and tumor necrosis factor receptor binding activity. Acts upstream of or within extrinsic apoptotic signaling pathway via death domain receptors and retinal cell programmed cell death. Located in external side of plasma membrane. Is expressed in several structures, including alimentary system; brain; hemolymphoid system gland; reproductive system; and trophectoderm. Used to study autoimmune lymphoproliferative syndrome and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including cholangiocarcinoma; chronic myeloid leukemia; diabetes mellitus (multiple); pancreatic Cancer (multiple); and pre-eclampsia (multiple). Orthologous to human FASLG (Fas ligand). [provided by Alliance of Genome Resources, Apr 2022]

Fasl 基因产物(2)

mRNA Protein Name
NM_001205243.1 NP_001192172.1 tumor necrosis factor ligand superfamily member 6 isoform 2
NM_010177.4 NP_034307.1 tumor necrosis factor ligand superfamily member 6 isoform 1
基因本体论
  • 生物过程
  • 细胞组分
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within apoptotic signaling pathway IDA
IDA: 通过直接分析推断
7511063 MGI
acts upstream of or within extrinsic apoptotic signaling pathway via death domain receptors IDA
IDA: 通过直接分析推断
10588860 MGI
acts upstream of or within retinal cell programmed cell death IMP
IMP: 通过突变表型推断
14517994 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell surface IDA
IDA: 通过直接分析推断
20404348 MGI
located in external side of plasma membrane IDA
IDA: 通过直接分析推断
16973387 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

tumor necrosis factor ligand superfamily member 6

CD95 ligand

Fas antigen ligand

generalized lymphoproliferative disease

tumor necrosis factor ligand 1a

重组 Fasl 蛋白

目录号 产品名 蛋白编号 纯度
HY-P74157 Fas Ligand Protein, Mouse (P.pastoris, His) Q544E9 (P132-L279) ≥95%
HY-P700176AF Animal-Free Fas Ligand Protein, Mouse (His) Q544E9 (Q128-L279) ≥95%

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-133897 (Rac)-Indoximod 98.13% 否
HY-150190 F5446 99.38% 否
HY-P10102 Kp7-6 Inhibitor 99.77% 否
HY-153161 CASP8-IN-1 Inhibitor 98.97% 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus Fasl NCBI
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