ARHGAP42 - Rho GTPase activating protein 42 Gene

中文名称：Rho GTP 酶激活蛋白 42

种属: Homo sapiens

同用名: AD031; GRAF3; TMEM133

关于 ARHGAP42

功能概要

该基因编码 Rho GTP 酶激活蛋白 (RhoGAP) ，以及 GRAF 或 BAR-PH 蛋白家族的成员。该基因的表达在血管平滑肌细胞中富集，编码的蛋白质抑制 RhoA 活性以调节血管张力和控制血压。该基因第一个内含子的突变调节其表达，并与临界高血压患者的血压降低有关。[RefSeq 提供，2017 年 7 月]

This gene encodes a Rho GTPase-activating protein (RhoGAP), and member of the GRAF or BAR-PH family of proteins. Expression of this gene is enriched in vascular smooth muscle cells and the encoded protein inhibits RhoA activity to regulate vascular tone and control blood pressure. A mutation in the first intron of this gene modulates its expression and is associated with reduced blood pressure in human patients with borderline hypertension. [provided by RefSeq, Jul 2017]