2. Gene
  3. Hbegf - heparin-binding EGF-like growth factor Gene

Hbegf - heparin-binding EGF-like growth factor Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Dtr; Dts; Hegfl

基因 ID: 15200 | 基因类型: protein coding

关于 Hbegf

功能概要

Enables epidermal growth factor receptor binding activity; growth factor activity; and heparin binding activity. Involved in positive regulation of keratinocyte migration; positive regulation of smooth muscle cell proliferation; and wound healing, spreading of epidermal cells. Acts upstream of or within several processes, including epidermal growth factor receptor signaling pathway; positive regulation of peptidyl-tyrosine phosphorylation; and regulation of heart contraction. Located in extracellular space. Is integral component of plasma membrane. Is expressed in several structures, including branchial arch; heart; oral region gland; telencephalon; and tooth. Human ortholog(s) of this gene implicated in glomerulosclerosis and perinatal necrotizing enterocolitis. Orthologous to human HBEGF (heparin binding EGF like growth factor). [provided by Alliance of Genome Resources, Apr 2022]

Hbegf 基因产物(1)

mRNA Protein Name
NM_010415.2 NP_034545.1 proheparin-binding EGF-like growth factor precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables epidermal growth factor receptor binding IDA
IDA: 通过直接分析推断
1840698 MGI
enables growth factor activity IDA
IDA: 通过直接分析推断
1840698 MGI
enables heparin binding IDA
IDA: 通过直接分析推断
1840698 MGI
enables receptor ligand activity IDA
IDA: 通过直接分析推断
12621152 MGI
enables receptor ligand activity IMP
IMP: 通过突变表型推断
12621152 MGI
enables transmembrane receptor protein tyrosine kinase activator activity IDA
IDA: 通过直接分析推断
12621152 MGI
enables transmembrane receptor protein tyrosine kinase activator activity IMP
IMP: 通过突变表型推断
12621152 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in ERBB2-EGFR signaling pathway IMP
IMP: 通过突变表型推断
21946538 MGI
involved in ERBB2-ERBB4 signaling pathway IMP
IMP: 通过突变表型推断
12621152 MGI
involved in cell migration IMP
IMP: 通过突变表型推断
15923649 MGI
acts upstream of or within epidermal growth factor receptor signaling pathway IDA
IDA: 通过直接分析推断
12621152 MGI
acts upstream of or within positive regulation of cell population proliferation IDA
IDA: 通过直接分析推断
8702723 MGI
involved in positive regulation of keratinocyte migration IMP
IMP: 通过突变表型推断
15923649 MGI
acts upstream of or within positive regulation of peptidyl-tyrosine phosphorylation IDA
IDA: 通过直接分析推断
8702723 MGI
involved in positive regulation of smooth muscle cell proliferation IDA
IDA: 通过直接分析推断
1840698 MGI
acts upstream of or within regulation of heart contraction IMP
IMP: 通过突变表型推断
12621152 MGI
involved in wound healing, spreading of epidermal cells IMP
IMP: 通过突变表型推断
15923649 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in extracellular space IDA
IDA: 通过直接分析推断
12621152 MGI
located in extracellular space IDA
IDA: 通过直接分析推断
9857183 MGI
located in plasma membrane IDA
IDA: 通过直接分析推断
9857183 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

proheparin-binding EGF-like growth factor

diphtheria toxin receptor

heparin binding epidermal growth factor-like growth factor

重组 Hbegf 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7194 HB-EGF Protein, Mouse Q06186 (D63-L148) ≥95%

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06029 HBEGF Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Hbegf NCBI NCBI:1839
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