HB-EGF 蛋白, Mouse

HB-EGF Protein, Mouse is shown to play a role in wound healing, cardiac hypertrophy, and heart development and function.

肝素结合表皮生长因子样生长因子 (HBEGF) 是 EGF 家族的肝素结合成员。它是成纤维细胞和平滑肌细胞的有效有丝分裂原和趋化因子。与其他 EGF 家族成员一样，HB-EGF 结合并激活 EGF 受体 1 和 4。HB-EGF 已被证明能够以自分泌或旁分泌方式刺激多种细胞的生长，并参与基质增殖。HB-EGF 也是肿瘤生长和血管生成的有效诱导剂^[1]。

The ED₅₀ is <1 ng/mL as measured by murine Balb/c 3T3 cells, corresponding to a specific activity of >1.0 × 10⁶IU/mg.

Mouse

E. coli

Tag Free

Q06186 (D63-L148)

15200  [NCBI]

DLEGTDLNLFKVAFSSKPQGLATPSKERNGKKKKKGKGLGKKRDPCLRKYKDYCIHGECRYLQEFRTPSCKCLPGYHGHRCHGLTL

Approximately 9.8 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized after extensive dialysis against 10 mM PB, 500 mM NaCl, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.

• [1]. Ongusaha PP, et al. HB-EGF is a potent inducer of tumor growth and angiogenesis. Cancer Res. 2004 Aug 1;64(15):5283-90.  [Content Brief]