1. Gene
  2. Hrh1 - histamine receptor H1 Gene

Hrh1 - histamine receptor H1 Gene

中文名称:组胺受体H1

种属: Mus musculus

同用名: H1R; Hir; Bphs; HH1R

基因 ID: 15465 | 基因类型: protein coding

关于 Hrh1

Chromosome 6: 114,374,897-114,460,257 forward strand.GRCm39:CM000999.3

This gene has 5 transcripts (splice variants), 186 orthologues, 32 paralogues and is associated with 39 phenotypes. Biased expression in cortex adult (RPKM 2.2), colon adult (RPKM 1.7) and 14 other tissues.

功能概要

预计该基因编码的蛋白具有多种功能,包括 G 蛋白偶联血清素受体活性;钙离子跨膜转运蛋白活性;和组胺结合活性。在内存上游或内存中执行操作;突触可塑性的调节;和视觉学习。预测位于胞质溶胶和质膜中。预计在树突中活跃。预计是质膜的组成部分。在大脑中表达;胃;和子宫。与人类 HRH1(组胺受体 H1)同源。 [由基因组资源联盟提供,2022 年 4 月]

Predicted to enable several functions, including G protein-coupled serotonin receptor activity; calcium ion transmembrane transporter activity; and histamine binding activity. Acts upstream of or within memory; regulation of synaptic plasticity; and visual learning. Predicted to be located in cytosol and plasma membrane. Predicted to be active in dendrite. Predicted to be integral component of plasma membrane. Is expressed in brain; stomach; and uterus. Orthologous to human HRH1 (Histamine Receptor H1). [provided by Alliance of Genome Resources, Apr 2022]

Hrh1 基因产物(7)

mRNA Protein Name
NM_001252643.3 NP_001239572.1 histamine H1 receptor
NM_008285.5 NP_032311.2 histamine H1 receptor
NM_001252642.3 NP_001239571.1 histamine H1 receptor
NM_001317125.2 NP_001304054.1 histamine H1 receptor
NM_001317124.2 NP_001304053.1 histamine H1 receptor
NM_001410031.1 NP_001396960.1 histamine H1 receptor
NM_001317126.2 NP_001304055.1 histamine H1 receptor
基因本体论
  • 生物过程
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within memory IMP
IMP: 通过突变表型推断
17145090 MGI
acts upstream of or within regulation of synaptic plasticity IMP
IMP: 通过突变表型推断
17145090 MGI
acts upstream of or within visual learning IMP
IMP: 通过突变表型推断
17145090 MGI
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

Hrh1 蛋白结构

7tmA_Histamine_H1R

7tmA_Histamine_H1R: cd15050 (28 - 479)

7tmA_Histamine_H1R

7tmA_Histamine_H1R: cd15050 (28 - 54)

7tmA_Histamine_H1R

7tmA_Histamine_H1R: cd15050 (61 - 87)

7tmA_Histamine_H1R

7tmA_Histamine_H1R: cd15050 (99 - 129)

7tmA_Histamine_H1R

7tmA_Histamine_H1R: cd15050 (141 - 162)

7tmA_Histamine_H1R

7tmA_Histamine_H1R: cd15050 (186 - 215)

7tmA_Histamine_H1R

7tmA_Histamine_H1R: cd15050 (217 - 438)

7tmA_Histamine_H1R

7tmA_Histamine_H1R: cd15050 (447 - 472)

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  • 488 a.a.
蛋白主名 其他名称

histamine H1 receptor

Bordetella pertussis induced histamine sensitization

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Hrh1 NCBI NCBI:3269