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  2. DAPK1 - death associated protein kinase 1 Gene

DAPK1 - death associated protein kinase 1 Gene

中文名称:死亡相关蛋白激酶 1

种属: Homo sapiens

同用名: DAPK; ROCO3

基因 ID: 1612 | 基因类型: protein coding

关于 DAPK1

Cytogenetic location: 9q21.33 Genomic coordinates (GRCh38): 9:87,497,228-87,708,634 (from NCBI)

This gene has 19 transcripts (splice variants), 211 orthologues and 4 paralogues. Ubiquitous expression in lung (RPKM 19.2), ovary (RPKM 16.6) and 25 other tissues.

功能概要

死亡相关蛋白激酶 1 是γ-干扰素诱导的程序性细胞死亡的正介质。 DAPK1 编码一种结构独特的 160-kD 钙调蛋白依赖性丝氨酸-苏氨酸激酶,它携带 8 个锚蛋白重复序列和 2 个推定的 P 环共有位点。它是一种肿瘤抑制候选物。可变剪接导致多个转录本变体。[RefSeq 提供,2013 年 12 月]

Death-associated protein kinase 1 is a positive mediator of gamma-interferon induced programmed cell death. DAPK1 encodes a structurally unique 160-kD Calmodulin dependent serine-threonine kinase that carries 8 ankyrin repeats and 2 putative P-loop consensus sites. It is a tumor suppressor candidate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

DAPK1 基因产物(4)

mRNA Protein Name
NM_001288729.2 NP_001275658.1 death-associated protein kinase 1
NM_001288730.2 NP_001275659.1 death-associated protein kinase 1
NM_001288731.2 NP_001275660.1 death-associated protein kinase 1
NM_004938.4 NP_004929.2 death-associated protein kinase 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ATP binding IDA
IDA: 通过直接分析推断
10629061 GOA
enables calcium/calmodulin-dependent protein kinase activity IDA
IDA: 通过直接分析推断
10629061 GOA
enables calmodulin binding IDA
IDA: 通过直接分析推断
10629061 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
19180116 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
15616583 GOA
enables protein kinase activity IDA
IDA: 通过直接分析推断
7828849 GOA
enables syntaxin-1 binding IPI
IPI: 通过物理相互作用推断
12730201 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within apoptotic process IGI
IGI: 通过遗传相互作用推断
7828849 GOA
involved in apoptotic process IMP
IMP: 通过突变表型推断
10629061 GOA
involved in apoptotic signaling pathway IMP
IMP: 通过突变表型推断
7828849 GOA
involved in cellular response to hydroperoxide IMP
IMP: 通过突变表型推断
22095288 GOA
involved in cellular response to type II interferon IDA
IDA: 通过直接分析推断
18995835 GOA
involved in defense response to tumor cell IMP
IMP: 通过突变表型推断
30429596 GOA
involved in intracellular signal transduction IDA
IDA: 通过直接分析推断
10629061 GOA
involved in negative regulation of translation IDA
IDA: 通过直接分析推断
18995835 GOA
involved in positive regulation of apoptotic process IMP
IMP: 通过突变表型推断
10629061 GOA
involved in positive regulation of autophagic cell death IMP
IMP: 通过突变表型推断
11980920 GOA
involved in positive regulation of autophagy IMP
IMP: 通过突变表型推断
22095288 GOA
involved in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
IDA: 通过直接分析推断
16132846 GOA
involved in protein autophosphorylation IDA
IDA: 通过直接分析推断
10629061 GOA
involved in protein phosphorylation IDA
IDA: 通过直接分析推断
10629061 GOA
involved in regulation of response to tumor cell IDA
IDA: 通过直接分析推断
11573098 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of DAPK1-calmodulin complex IPI
IPI: 通过物理相互作用推断
20103772 GOA
located in actin cytoskeleton IDA
IDA: 通过直接分析推断
10629061 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
12730201 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
12730201 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

DAPK1 蛋白结构

Pkinase

Pkinase: Protein kinase domain (13 - 275)

Ank_4

Ank_4: Ankyrin repeats (many copies) (345 - 399)

Ank_2

Ank_2: Ankyrin repeats (3 copies) (418 - 508)

Ank

Ank: Ankyrin repeat (511 - 542)

Ank_2

Ank_2: Ankyrin repeats (3 copies) (548 - 637)

Death

Death: Death domain (1312 - 1393)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1430 a.a.
蛋白主名 其他名称

death-associated protein kinase 1

DAP kinase 1

重组 DAPK1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P76858 DAPK1 Protein, Human (sf9, His-GST) P53355-1 (M1-L363) ≥95%

关联疾病

疾病名称 别名
Pancreatic Ductal Adenocarcinoma

Ductal Adenocarcinoma Of The Pancreas

Cervical Squamous Cell Carcinoma

Squamous Cell Carcinoma Of The Cervix Uteri

Squamous Cell Carcinoma Of Cervix

Bladder Cancer

Urinary Bladder Cancer

Bladder Carcinoma

Urinary Bladder Carcinoma

Bladder Neoplasm

Bladder Tumor

Cancer, Bladder

Malignant Neoplasm Of Urinary Bladder

Carcinoma Of Bladder

Bladder Cancer, Somatic

Tumor Of The Bladder

Carcinoma Of Urinary Bladder

Bladder Carcinoma Urinary

Cancer Of The Urinary Bladder

Cancer, Urinary Bladder

Malignant Bladder Neoplasm

Malignant Bladder Tumor

Neoplasm Of The Bladder

Neoplasm Of The Urinary Bladder

Tumor Of The Urinary Bladder

Urinary Bladder Neoplasm

BLC

Urothelial Carcinoma Of The Bladder

Bladder Tumors

Urinary Bladder Neoplasms

Bladder Cancer Nos

Vesical Cancer Nos

Malignant Neoplasm Of Bladder, Part Unspecified

Malignant Tumour Of Urinary Bladder

Primary Malignant Neoplasm Of Bladder

Ischemia

Acute Coronary Syndrome

Transitional Cell Carcinoma

Transitional Cell Neoplasm

Carcinoma, Transitional Cell

Transitional Carcinoma

Transitional Cell Tumor

Urothelial Cell Carcinoma

Carcinoma Transitional Cell

Transitional Cell Carcinoma Of Bladder

Cholecystitis

Acute Cholecystitis

Chronic Cholecystitis

Acalculous Cholecystitis

Acute And Chronic Cholecystitis

Acute On Chronic Cholecystitis

Gallstone Cholecystitis

Cholecystitis, Acute

Calculus Of Gallbladder With Cholecystitis

Gallbladder Inflammation

Acute Cholecystitis Infection

Acute Acalculous Cholecystitis

Chronic Acalculous Cholecystitis

Nonfunctioning Gallbladder

Adenoid Cystic Carcinoma

Adenocystic Carcinoma

Cribriform Carcinoma

Cylindroma

Carcinoma Adenoid Cystic

Carcinoma, Adenoid Cystic

Adenoid Cystic Carcinoma Of Salivary Gland

Eccrine Dermal Cylindroma

Carcinoma, Cribriform

Squamous Cell Carcinoma

Epidermoid Carcinoma

Squamous Cell Cancer

Carcinoma, Squamous Cell

Squamous Cell Skin Cancer

Malignant Squamous Cell Tumor

Squamous Carcinoma

Squamous Cell Epithelioma

Carcinoma Squamous Cell

Neoplasms, Squamous Cell

Squamous Cell Carcinoma - Category

Malignant Squamous Cell Neoplasm

Squamous Cell Carcinoma Of Skin

Cervical Cancer

Cervical Cancer, Somatic

Neoplasm Of Uterine Cervix

Cervix Cancer

Uterine Cervical Neoplasm

Cervical Neoplasm

Cervix Uteri Cancer

Tumor Of The Cervix Uteri

CERCA

Uterine Cervical Cancer

Neoplasms Cervical

Uterine Cervical Neoplasms

Cervical Cancers

Cancer, Cervical, Somatic

Malignant Tumor Of Cervix

Cervix Carcinoma

Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma

B-Cell Lymphoma

Lymphoma, B-Cell

B-Cell Lymphomas

B-Cell Lymphocytic Neoplasm

Lymphoma B-Cell

B-Cell Lymphoma Nos

Gastric Cancer

Stomach Cancer

Gastric Carcinoma

Stomach Carcinoma

Gastric Cancer, Somatic

Gastric Neoplasm

Carcinoma Of Stomach

Stomach Neoplasms

Malignant Neoplasm Of Stomach

Gastric Cancer Risk After H. Pylori Infection

Cancer Of The Stomach

Adult Stomach Cancer

Adult Stomach Carcinoma

GASC

Gastric Cancer Intestinal

Gastric Cancers

Gastric Carcinomas

Cancer, Gastric

Stomach Neoplasm

Malignant Neoplasm Of Body Of Stomach

Malignant Tumor Of Lesser Curve Of Stomach

Gastrocarcinoma Of Unspecified Site

Leather Bottle Stomach

Carcinoma Of Fundus Of Stomach

Cancer Of Fundus Of Stomach

Primary Malignant Neoplasm Of Body Of Stomach

Cancer Of Body Of Stomach

Primary Malignant Neoplasm Of Pyloric Antrum

Pyloric Antrum Cancer

Malignant Tumour Of Stomach

Oligodendroglioma

Oligodendroglial Neoplasm

Oligodendroglial Tumor

Oligodendroglial Tumors

Well Differentiated Oligodendroglioma

Nasopharyngeal Carcinoma

Malignant Neoplasm Of Nasopharynx

Npc

Nasopharyngeal Cancer

Nasopharyngeal Carcinoma 1

Nasopharynx Carcinoma

Nasopharyngeal Neoplasms

Npca

Carcinoma Of Nasopharynx

Malignant Nasopharyngeal Tumor

Nasopharynx Cancer

Squamous Cell Carcinoma Of The Nasopharynx

Nasopharyngeal Neoplasm

Cancer Of Nasopharynx

Esophageal Cancer

Esophageal Carcinoma

Carcinoma Of Esophagus

Esophageal Squamous Cell Carcinoma, Somatic

Esophageal Carcinoma, Somatic

Esophagus Cancer

Gastric Cardia Adenocarcinoma

Esophageal Neoplasms

Esophageal Cancer, Somatic

Cancer Of Esophagus

Cancer Of Oesophagus

Carcinoma Of Oesophagus

Ca Lower Third Oesophagus

Ca Middle Third Oesophagus

Malignant Neoplasm Of Distal Third Of Esophagus

Malignant Neoplasm Of Lower Third Of Oesophagus

Malignant Neoplasm Of Middle Third Of Oesophagus

Malignant Neoplasm Of Proximal Third Of Esophagus

Malignant Neoplasm Of Upper Third Esophagus

Malignant Tumor Of Abdominal Esophagus

Malignant Tumor Of Distal Third Of Esophagus

Malignant Tumor Of Proximal Third Of Esophagus

Malignant Tumor Of The Middle Third Of The Esophagus

ESCR

Aerodigestive Tract Cancer

Escc

Esophageal Squamous Cell Carcinoma

Cancer, Esophageal

Malignant Neoplasm Of Esophagus

Squamous Cell Carcinoma Of Esophagus

Malignant Neoplasm Of Middle Third Of Esophagus

Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon

Primary Central Nervous System Lymphoma

Pcnsl

Primary Cns Lymphoma

Primary Brain Lymphoma

Primary Lymphoma, Cns

Primary Cerebral Lymphoma

Mixed Oligodendroglioma-Astrocytoma

Who Grade Ii Mixed Glioma

Cholangiocarcinoma

Cholangiocarcinoma, Susceptibility To

Extrahepatic Cholangiocarcinoma

Intrahepatic Cholangiocarcinoma

Chlc

Chlc, Susceptibility To

Cc

Cholangiocarcinoma Of Biliary Tract

Cholangiocellular Carcinoma

Distal Cholangiocarcinoma

Perihilar Cholangiocarcinoma

Bile Duct Cancer

Cca

Adult Primary Cholangiocellular Carcinoma

Bile Duct Carcinoma

Ovarian Cancer

Ovarian Carcinoma

Ovarian Neoplasm

Malignant Tumour Of Ovary

Cancer Of The Ovary

Epithelial Ovarian Cancer

Neoplasm Of Ovary

Ovarian Neoplasms

Ovarian Cancers

Malignant Neoplasm Of Ovary

Primary Malignant Neoplasm Of Ovary

Ovarian Cancer, Somatic

Malignant Ovarian Tumor

Ovary Neoplasm

Primary Ovarian Cancer

Tumor Of The Ovary

Malignant Neoplasm Of The Ovary

Malignant Tumor Of The Ovary

Ovarian Malignant Tumor

OC

Ovarian Carcinomas

Cancer, Ovarian

Cancer Of Ovary

Ovary Cancer

Ca Ovary

Lung Cancer Susceptibility 3

Lung Adenocarcinoma

Adenocarcinoma Of Lung

LNCR3

Adenocarcinoma Of Lung, Susceptibility To

Bronchogenic Lung Adenocarcinoma

Nonsmall Cell Adenocarcinoma

Adenocarcinoma Lung

Lung Adenocarcinomas

Non-Small Cell Adenocarcinoma

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus DAPK1 RGD RGD:1311629
Bos taurus DAPK1 VGNC VGNC:27877
Macaca mulatta DAPK1 VGNC VGNC:71732
Canis familiaris DAPK1 VGNC VGNC:39770
Mus musculus DAPK1 MGD MGI:1916885
Felis catus DAPK1 VGNC VGNC:61337
Others DAPK1 NCBI