2. Apoptosis
  3. DAPK
  4. TAT-GluN2BCTM

TAT-GluN2BCTM 是一种膜渗透性的 DAPK1 靶向肽。TAT-GluN2BCTM 能将活性 DAPK1 靶向到溶酶体进行降解。TAT-GluN2BCTM 可通过敲低 DAPK1，保护神经元免受氧化应激以及 NMDAR- 介导的兴奋性毒性。TAT-GluN2BCTM 可用于神经保护的研究。

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Custom Peptide Synthesis

TAT-GluN2BCTM Chemical Structure

TAT-GluN2BCTM Chemical Structure

CAS No. : 1587742-50-4

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TAT-GluN2BCTM 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TAT-GluN2BCTM is a membrane-permeable DAPK1-targeting peptide. TAT-GluN2BCTM targets active DAPK1 to lysosomes for degradation. TAT-GluN2BCTM protects neurons from oxidative stress and NMDAR-mediated excitotoxicity by knocking down DAPK1. TAT-GluN2BCTM can be used in the study of neuroprotection[1].

IC50 & Target

DAPK1[1].
体外研究
(In Vitro)

TAT-GluN2BCTM (200 µM; 0.5, 2, 4 h) 以时间依赖性的方式降低 NMDA 处理的原代神经元培养物中 DAPK1 的水平[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

TAT-GluN2BCTM 相关抗体:

Western Blot Analysis[1]

Cell Line: primary neuronal cultures (NMDA-treated)
Concentration: 200 µM
Incubation Time: 0.5, 2, 4 h
Result: Reduced DAPK1 levels in a time-dependent manner.
体内研究
(In Vivo)

TAT-GluN2BCTM (10 mg/kg; i.v.; single) 导致大鼠大脑缺血侧的 DAPK1 水平显着降低[1]。
TAT-GluN2BCTM (10 mg/kg; i.v.; single) 在大鼠的皮质和纹状体中显示出显着的神经保护作用[1]。
TAT-GluN2BCTM 能够特异性敲低 DAPK1 的活性（但不是非活性）形式[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Focal ischemia rat model[1].
Dosage: 10 mg/kg
Administration: Intravenous injection; single.
Result: Reduced the levels of DAPK1 only in the ischemic side of the brain.
Significantly reduced the numbers of degenerating neurons in both striatum and cortical areas.
分子量

5135.91

Formula

C224H374N86O54
CAS 号
Sequence

Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Lys-Lys-Asn-Arg-Asn-Lys-Leu-Arg-Arg-Gln-His-Ser-Tyr-Lys-Phe-Glu-Arg-Gln-Lys-Ile-Leu-Asp-Gln-Arg-Phe-Phe-Glu
Sequence Shortening

YGRKKRRQRRRKKNRNKLRRQHSYKFERQKILDQRFFE
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

TAT-GluN2BCTM 相关分类

  • 摩尔计算器

  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TAT-GluN2BCTM1587742-50-4DAPKDeath associated protein kinaseDAPK1neurons protectionoxidative stressInhibitorinhibitorinhibit

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