2. Gene
  3. P2rx1 - purinergic receptor P2X, ligand-gated ion channel, 1 Gene

P2rx1 - purinergic receptor P2X, ligand-gated ion channel, 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：嘌呤能受体 P2 X，配体门控离子通道，1

种属: Mus musculus

同用名: P2x; RP-2; Pdcd3

基因 ID: 18436 | 基因类型: protein coding

关于 P2rx1

Chromosome 11: 72,889,929-72,906,026 forward strand.GRCm39:CM001004.3

This gene has 3 transcripts (splice variants), 199 orthologues, 6 paralogues and is associated with 5 phenotypes. Biased expression in bladder adult (RPKM 22.3) and thymus adult (RPKM 21.4).

功能概要

该基因编码的蛋白可启动阳离子通道活性和嘌呤能核苷酸受体活性。在几个过程的上游或内部起作用，包括激活参与细胞凋亡过程的半胱氨酸型内肽酶活性；离子传输的调节；和血小板分泌血清素。位于质膜和突触后膜的外侧。以多种结构表达，包括膀胱；前肠-中肠交界处；心;肝叶;和中肠。与人 P2RX1（嘌呤能受体 P2X 1）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables cation channel activity and purinergic nucleotide receptor activity. Acts upstream of or within several processes, including activation of cysteine-type endopeptidase activity involved in apoptotic process; regulation of ion transport; and serotonin secretion by platelet. Located in external side of plasma membrane and postsynaptic membrane. Is expressed in several structures, including bladder; foregut-midgut junction; heart; liver lobe; and midgut. Orthologous to human P2RX1 (purinergic receptor P2X 1). [provided by Alliance of Genome Resources, Apr 2022]

P2rx1 基因产物(1)

mRNA Protein Name
NM_008771.3 NP_032797.3 P2X purinoceptor 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables monoatomic cation channel activity IMP
IMP: 通过突变表型推断
10638758 MGI
enables purinergic nucleotide receptor activity IMP
IMP: 通过突变表型推断
10638758 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within activation of cysteine-type endopeptidase activity involved in apoptotic process IDA
IDA: 通过直接分析推断
16325464 MGI
acts upstream of or within ceramide biosynthetic process IDA
IDA: 通过直接分析推断
16325464 MGI
acts upstream of establishment of localization in cell IGI
IGI: 通过遗传相互作用推断
15914557 MGI
acts upstream of establishment of localization in cell IMP
IMP: 通过突变表型推断
15914557 MGI
acts upstream of or within establishment of localization in cell IMP
IMP: 通过突变表型推断
10638758 MGI
acts upstream of or within insemination IMP
IMP: 通过突变表型推断
10638758 MGI
acts upstream of monoatomic ion transport IGI
IGI: 通过遗传相互作用推断
15914557 MGI
acts upstream of monoatomic ion transport IMP
IMP: 通过突变表型推断
15914557 MGI
acts upstream of or within monoatomic ion transport IMP
IMP: 通过突变表型推断
10638758 MGI
acts upstream of or within platelet activation IMP
IMP: 通过突变表型推断
12913094 MGI
acts upstream of or within positive regulation of monoatomic ion transport IGI
IGI: 通过遗传相互作用推断
15914557 MGI
acts upstream of or within positive regulation of monoatomic ion transport IMP
IMP: 通过突变表型推断
15914557 MGI
acts upstream of or within regulation of calcium ion transport IMP
IMP: 通过突变表型推断
16920810 MGI
acts upstream of or within regulation of smooth muscle contraction IMP
IMP: 通过突变表型推断
10638758 MGI
acts upstream of or within regulation of vascular associated smooth muscle contraction IMP
IMP: 通过突变表型推断
16920810 MGI
acts upstream of or within regulation of vasoconstriction IMP
IMP: 通过突变表型推断
14679185 MGI
acts upstream of or within response to ATP IMP
IMP: 通过突变表型推断
14679185 MGI
acts upstream of or within serotonin secretion by platelet IMP
IMP: 通过突变表型推断
12913094 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in external side of plasma membrane IDA
IDA: 通过直接分析推断
11570704 MGI
located in postsynaptic membrane IDA
IDA: 通过直接分析推断
11668586 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

P2rx1 蛋白结构

P2X

P2X: TIGR00863 (0 - 367)

  • 0
  • 100
  • 200
  • 300
  • 399 a.a.
蛋白主名 其他名称

P2X purinoceptor 1

ATP receptor

P2X1 receptor

programmed cell death 3

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09897 P2RX1 Human Pre-designed siRNA Set A / 否
HY-RS09898 P2rx1 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS09899 P2rx1 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens P2rx1 NCBI NCBI:5023
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