2. Gene
  3. EFNA4 - ephrin A4 Gene

EFNA4 - ephrin A4 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：肾上腺素 A4

种属: Homo sapiens

同用名: EFL4; EPLG4; LERK4; LERK-4

基因 ID: 1945 | 基因类型: protein coding

关于 EFNA4

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:155,063,740-155,069,553 (from NCBI)

This gene has 3 transcripts (splice variants), 149 orthologues and 7 paralogues. Ubiquitous expression in skin (RPKM 7.7), colon (RPKM 6.4) and 23 other tissues.

功能概要

该基因编码肝配蛋白 (EPH) 家族的一个成员。肝配蛋白和 EPH 相关受体包含受体蛋白-酪氨酸激酶的最大亚家族，并且与介导发育事件有关，尤其是在神经系统和红细胞生成中。基于它们的结构和序列关系，肝配蛋白分为肝配蛋白-A (EFNA) 类和肝配蛋白 B (EFNB) 类，前者通过糖基磷脂酰肌醇键固定在膜上，后者是跨膜蛋白。该基因编码一种 EFNA 类肝配蛋白，该蛋白与多种癌症的增殖和转移有关。[RefSeq 提供，2022 年 5 月]

This gene encodes a member of the ephrin (EPH) family. The Ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, Ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin that has been implicated in proliferation and metastasis of several types of cancers. [provided by RefSeq, May 2022]

EFNA4 基因产物(4)

mRNA Protein Name
NM_001406810.1 NP_001393739.1 ephrin-A4 isoform d
NM_005227.3 NP_005218.1 ephrin-A4 isoform a precursor
NM_182689.2 NP_872631.1 ephrin-A4 isoform b precursor
NM_182690.3 NP_872632.2 ephrin-A4 isoform c precursor
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ephrin receptor binding IPI
IPI: 通过物理相互作用推断
11519828 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
15777695 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

EFNA4 蛋白结构

Ephrin

Ephrin: Ephrin (25 - 155)

  • 0
  • 100
  • 201 a.a.
蛋白主名 其他名称

ephrin-A4

eph-related receptor tyrosine kinase ligand 4

重组 EFNA4 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70376 Ephrin-A4/EFNA4 Protein, Human (HEK293, His) P52798 (L26-G171) ≥95%
HY-P73010 Ephrin-A4/EFNA4 Protein, Human (HEK293, Fc) P52798 (L26-G171) ≥95%

关联疾病

疾病名称 别名
Craniofrontonasal Syndrome

Craniofrontonasal Dysplasia

CFNS

Cfnd

Craniofrontonasal Dysostosis

Craniofrontonasal Dystosis

Dysplasia, Craniofrontonasal
Craniosynostosis

Premature Closure Of Cranial Sutures

Craniostenosis

Craniosynostosis Syndrome

Cso

Craniosynostoses

Congenital Ossification Of Cranial Sutures

Congenital Ossification Of Sutures Of Skull

Craniostosis

Imperfect Fusion Of Skull

Congenital Imperfect Closure Skull

Imperfect Closure Skull

Premature Closure Cranium Sutures

Deficiency Of Craniofacial Axis
Muenke Syndrome

Muenke Nonsyndromic Coronal Craniosynostosis

Fgfr3-Related Craniosynostosis

Fgfr3-Associated Coronal Synostosis

Coronal Craniosynostosis

MNKES

Syndrome Of Coronal Craniosynostosis

MNKS

Fgfr3-Related Isolated Coronal Synostosis

Muenke Non-Syndromic Coronal Craniosynostosis
Saethre-Chotzen Syndrome

SCS

Acs3

Acs Iii

Chotzen Syndrome

Acrocephaly, Skull Asymmetry, And Mild Syndactyly

Acrocephalosyndactyly Type 3

Acrocephalosyndactyly, Type Iii

Acrocephalosyndactyly Type Iii

Saethre-Chotzen Syndrome With Or Without Eyelid Anomalies

Auralcephalosyndactyly

Acs 3

Acrocephalo-Syndactyly, Type 3

Blepharophimosis,Epicanthus Inversus, And Ptosis 3

Aural Cephalosyndactyly

Kurczynski-Casperson Syndrome

Acrocephalosyndactyly Iii

Dysostosis Craniofacialis With Hypertelorism

Saethre-Chotzen Syndrome, With/Without Eyelid Anomalies

Sakati Syndrome
Apert Syndrome

Acrocephalosyndactyly Type I

Acs1

Acrocephalosyndactylia

Acrocephalosyndactyly

Acs I

Apert-Crouzon Disease

Acrocephalosyndactyly Type 1

Acrocephalosyndactyly, Type I

Acs 1

Acrocephalo-Syndactyly Type 1

Syndactylic Oxycephaly

Apert'S Syndrome

Type I Acrocephalosyndactyly

APRS
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS04195 EFNA4 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus EFNA4 VGNC VGNC:107870
Rattus norvegicus EFNA4 RGD RGD:1307808
Canis familiaris EFNA4 VGNC VGNC:40227
Mus musculus EFNA4 MGD MGI:106643
Bos taurus EFNA4 VGNC VGNC:28357
Others EFNA4 NCBI
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