1. Gene
  2. TRIM65 - tripartite motif containing 65 Gene

TRIM65 - tripartite motif containing 65 Gene

中文名称:含三方基序 65

种属: Homo sapiens

同用名: 4732463G12Rik

基因 ID: 201292 | 基因类型: protein coding

关于 TRIM65

Cytogenetic location: 17q25.1 Genomic coordinates (GRCh38): 17:75,879,537-75,896,951 (from NCBI)

This gene has 7 transcripts (splice variants), 102 orthologues and 80 paralogues. Ubiquitous expression in spleen (RPKM 5.1), lung (RPKM 4.3) and 25 other tissues.

功能概要

预测可启用锌离子结合活性。参与自噬的正向调节。位于细胞质和核质中。 [由基因组资源联盟提供,2022 年 4 月]

Predicted to enable zinc ion binding activity. Involved in positive regulation of Autophagy. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

TRIM65 基因产物(2)

mRNA Protein Name
NM_001256124.2 NP_001243053.1 tripartite motif-containing protein 65 isoform 2
NM_173547.4 NP_775818.2 tripartite motif-containing protein 65 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ubiquitin protein ligase activity IDA
IDA: 通过直接分析推断
28594402 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of inflammatory response IDA
IDA: 通过直接分析推断
31310649 GOA
involved in positive regulation of autophagy IMP
IMP: 通过突变表型推断
26347139 GOA
involved in positive regulation of interferon-beta production IDA
IDA: 通过直接分析推断
28594402 GOA
involved in protein K48-linked ubiquitination IDA
IDA: 通过直接分析推断
31310649 GOA
involved in protein K63-linked ubiquitination IDA
IDA: 通过直接分析推断
28594402 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in cytoplasm IDA
IDA: 通过直接分析推断
34512673 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

TRIM65 蛋白结构

zf-C3HC4

zf-C3HC4: Zinc finger, C3HC4 type (RING finger) (12 - 50)

zf-B_box

zf-B_box: B-box zinc finger (92 - 126)

SPRY

SPRY: SPRY domain (382 - 494)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 517 a.a.
蛋白主名 其他名称

tripartite motif-containing protein 65

直系同源

种属 基因名 来源 基因 ID
Felis catus TRIM65 VGNC VGNC:99565
Bos taurus TRIM65 VGNC VGNC:36347
Mus musculus TRIM65 MGD MGI:2442815
Rattus norvegicus TRIM65 RGD RGD:1559497
Canis familiaris TRIM65 VGNC VGNC:47832