1. Gene
  2. Slc22a12 - solute carrier family 22 (organic anion/cation transporter), member 12 Gene

Slc22a12 - solute carrier family 22 (organic anion/cation transporter), member 12 Gene

中文名称:溶质载体家族 22 (有机阴离子/阳离子转运蛋白) ,成员 12

种属: Mus musculus

同用名: Rst; OAT4L; URAT1; Slc22al2

基因 ID: 20521 | 基因类型: protein coding

关于 Slc22a12

Chromosome 19: 6,585,875-6,593,062 reverse strand.GRCm39:CM001012.3

This gene has 3 transcripts (splice variants), 475 orthologues, 26 paralogues and is associated with 5 phenotypes. Restricted expression toward kidney adult (RPKM 561.9).

功能概要

该基因编码的蛋白可启动尿酸盐跨膜转运蛋白活性。作用于尿酸盐运输的上游或内部。位于刷状缘膜。是膜的组成部分。在中枢神经系统中表达;背根神经节;雄性生殖腺或器官;后肾;和视网膜层。与人类 SLC22A12 同源(溶质载体家族 22 成员 12)。 [由基因组资源联盟提供,2022 年 4 月]

Enables urate transmembrane transporter activity. Acts upstream of or within urate transport. Located in brush border membrane. Is integral component of membrane. Is expressed in central nervous system; dorsal root ganglion; male reproductive gland or organ; metanephros; and retina layer. Orthologous to human SLC22A12 (solute carrier family 22 member 12). [provided by Alliance of Genome Resources, Apr 2022]

Slc22a12 基因产物(1)

mRNA Protein Name
NM_009203.3 NP_033229.3 solute carrier family 22 member 12
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
14531806 MGI
enables urate transmembrane transporter activity IDA
IDA: 通过直接分析推断
14747372 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within urate transport IDA
IDA: 通过直接分析推断
14747372 MGI
involved in urate transport IDA
IDA: 通过直接分析推断
14747372 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in brush border membrane IDA
IDA: 通过直接分析推断
14747372 MGI
located in membrane IDA
IDA: 通过直接分析推断
14747372 MGI
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

Slc22a12 蛋白结构

MFS_OAT

MFS_OAT: cd17374 (108 - 515)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 553 a.a.
蛋白主名 其他名称

solute carrier family 22 member 12

renal-specific transporter

solute carrier family 22 (organic cation transporter)-like 2

urate anion exchanger 1

urate:anion antiporter SLC22A12

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Slc22a12 NCBI NCBI:116085