1. Gene
  2. CELA3B - chymotrypsin like elastase 3B Gene

CELA3B - chymotrypsin like elastase 3B Gene

中文名称:胰凝乳蛋白酶样弹性蛋白酶 3B

种属: Homo sapiens

同用名: CBPP; ELA3B

基因 ID: 23436 | 基因类型: protein coding

关于 CELA3B

Cytogenetic location: 1p36.12 Genomic coordinates (GRCh38): 1:21,977,022-21,998,642 (from NCBI)

This gene has 4 transcripts (splice variants), 257 orthologues and 6 paralogues. Restricted expression toward pancreas (RPKM 10341.0).

功能概要

弹性蛋白酶形成丝氨酸蛋白酶的一个亚家族,除了弹性蛋白之外,它还能水解许多蛋白质。人类有六个弹性蛋白酶基因,它们编码结构相似的蛋白质弹性蛋白酶 1、2、2A、2B、3A 和 3B。与其他弹性蛋白酶不同,弹性蛋白酶 3B 几乎没有弹性分解活性。与大多数人类弹性蛋白酶一样,弹性蛋白酶 3B 作为酶原从胰腺分泌,并且与其他丝氨酸蛋白酶 (例如胰蛋白酶、胰凝乳蛋白酶和激肽释放酶) 一样,它在肠道中具有消化功能。弹性蛋白酶 3B 优先切割丙氨酸残基后的蛋白质。弹性蛋白酶 3B 也可能在胆固醇的肠道转运和代谢中发挥作用。弹性蛋白酶 3A 和弹性蛋白酶 3B 都被称为蛋白酶 E 和弹性蛋白酶 1,并且这种蛋白质在粪便中的排泄在临床试验中经常用作胰腺功能的量度。[RefSeq 提供,2009 年 5 月]

Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six Elastase genes which encode the structurally similar proteins Elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, Elastase 3B has little elastolytic activity. Like most of the human elastases, Elastase 3B is secreted from the pancreas as a zymogen and, like other serine proteases such as trypsin, chymotrypsin and Kallikrein, it has a digestive function in the intestine. Elastase 3B preferentially cleaves proteins after alanine residues. Elastase 3B may also function in the intestinal transport and metabolism of Cholesterol. Both Elastase 3A and Elastase 3B have been referred to as Protease E and as Elastase 1, and excretion of this protein in fecal material is frequently used as a measure of pancreatic function in clinical assays. [provided by RefSeq, May 2009]

CELA3B 基因产物(1)

mRNA Protein Name
NM_007352.4 NP_031378.1 chymotrypsin-like elastase family member 3B preproprotein

CELA3B 蛋白结构

Trypsin

Trypsin: Trypsin (29 - 263)

  • 0
  • 100
  • 200
  • 270 a.a.
蛋白主名 其他名称

chymotrypsin-like elastase family member 3B

cholesterol-binding pancreatic protease

关联疾病

疾病名称 别名
Exocrine Pancreatic Insufficiency
Pancreatic Steatorrhea

Pancreatic Steatorrhoea

Decreased Tolerance Of Pancreas

Pancreatic Disturbance Of Fat Absorption

Pancreatitis

Mumps Pancreatitis

Autoimmune Pancreatitis

Lymphoplasmocytic Sclerosing Pancreatitis

Aip

Common Bile Duct Disease

Common Bile Duct Diseases

Pancreatic Serous Cystadenoma
Acute Necrotizing Pancreatitis

Pancreatitis, Acute Necrotizing

Choledocholithiasis
Cystic Fibrosis

Mucoviscidosis

CF

Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis

Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis

Cystic Fibrosis Lung Disease, Modifier Of

Cystic Fibrosis Of Pancreas

Fibrocystic Disease Of Pancreas

Cf - [Cystic Fibrosis]

Cystic Fibrosis Nos

Fibrocystic Disease

Fibrocystic Disease Of The Pancreas

Mucoviscidosis Of Pancreas

Nonproliferative Fibrocystic Disease

Pancreatic Cystic Fibrosis

Celiac Disease 1

Celiac Disease

Coeliac Disease

Celiac Sprue

Celiac Disease, Susceptibility To

Gluten-Sensitive Enteropathy

Nontropical Sprue

Sprue

CELIAC1

Celiac Disease, Susceptibility To, 1

Celiac Sprue 1

Celiac Sprue, Susceptibility To, 1

Gluten-Sensitive Enteropathy 1

Gluten-Sensitive Enteropathy, Susceptibility To, 1

Idiopathic Steatorrhea

Cœliac Disease

Gluten Intolerance

Gluten-Induced Enteropathy

Gluten Enteropathy

Celiac Disease, Susceptibility To, Type 1

Childhood Celiac Disease

Coeliac Rickets

Gee Disease

Gee-Herter Disease

Heubner-Herter Disease

Idiopathic Steatorrhoea

Thaysen'S Disease

Herter Gee Syndrome

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus CELA3B RGD RGD:1307819
Mus musculus CELA3B NCBI NCBI:67868