Comt - catechol-O-methyltransferase Gene

中文名称：儿茶酚-O-甲基转移酶

种属: Rattus norvegicus

关于 Comt

功能概要

该基因编码的蛋白可启动儿茶酚 O-甲基转移酶活性。涉及多个过程，包括学习或记忆；平滑肌细胞增殖的负调节；和调节细胞胺代谢过程。位于多个细胞成分中，包括细胞体；树突棘;和突触后膜。用于研究帕金森病和高血压。高血压的生物标志物。该基因的人类直系同源物与多种疾病有关，包括注意力缺陷多动障碍；皮肤和结缔组织的自身免疫性疾病（多种）；神经性贪食症;认知障碍（多种）；和生殖器官癌（多发性）。与人类 COMT（儿茶酚-O-甲基转移酶）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables catechol O-methyltransferase activity. Involved in several processes, including learning or memory; negative regulation of smooth muscle cell proliferation; and regulation of cellular amine metabolic process. Located in several cellular components, including cell body; dendritic spine; and postsynaptic membrane. Used to study Parkinsonism and hypertension. Biomarker of hypertension. Human ortholog(s) of this gene implicated in several diseases, including attention deficit hyperactivity disorder; autoimmune disease of skin and connective tissue (multiple); bulimia nervosa; cognitive disorder (multiple); and reproductive organ Cancer (multiple). Orthologous to human COMT (catechol-O-methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]