2. Gene
  3. Bdkrb2 - bradykinin receptor B2 Gene

Bdkrb2 - bradykinin receptor B2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：缓激肽受体 B2

种属: Rattus norvegicus

同用名: B2BKR; B2BRA

基因 ID: 25245 | 基因类型: protein coding

关于 Bdkrb2

Primary_assembly 6: 124,472,566-124,502,497 forward strand.mRatBN7.2:CM026979.1

This gene has 2 transcripts (splice variants), 362 orthologues, 8 paralogues and is associated with 40 phenotypes. Biased expression in Adrenal (RPKM 44.5), Uterus (RPKM 44.) and 8 other tissues.

功能概要

该基因编码的蛋白可启动 beta-2 肾上腺素能受体结合活性和缓激肽受体活性。参与多个过程，包括对抗原刺激的急性炎症反应；细胞对缺氧的反应；和维持血脑屏障。位于质膜。用于研究多种疾病，包括哮喘；胰腺炎;胸膜炎;门静脉高压症;和肺动脉高压。高级别胶质瘤的生物标志物；高血压;心肌梗塞;和坐骨神经病。与哮喘有关的该基因的人类直系同源物；慢性阻塞性肺疾病;高血压;和鼻炎。与人 BDKRB2（缓激肽受体 B2）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables beta-2 Adrenergic Receptor binding activity and Bradykinin Receptor activity. Involved in several processes, including acute inflammatory response to antigenic stimulus; cellular response to hypoxia; and maintenance of blood-brain barrier. Located in plasma membrane. Used to study several diseases, including asthma; pancreatitis; pleurisy; portal hypertension; and pulmonary hypertension. Biomarker of high grade glioma; hypertension; myocardial infarction; and sciatic neuropathy. Human ortholog(s) of this gene implicated in asthma; chronic obstructive pulmonary disease; hypertension; and rhinitis. Orthologous to human BDKRB2 (Bradykinin Receptor B2). [provided by Alliance of Genome Resources, Apr 2022]

Bdkrb2 基因产物(2)

mRNA Protein Name
NM_173100.3 NP_775123.2 B2 bradykinin receptor isoform 2
NM_001270713.2 NP_001257642.1 B2 bradykinin receptor isoform 1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables beta-2 adrenergic receptor binding IPI
IPI: 通过物理相互作用推断
20150590 RGD
enables bradykinin receptor activity IDA
IDA: 通过直接分析推断
1715575 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
12177051 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in acute inflammatory response to antigenic stimulus IMP
IMP: 通过突变表型推断
7791078 RGD
involved in cellular response to hypoxia IEP
IEP: 通过表达模式推断
19565561 RGD
involved in maintenance of blood-brain barrier IDA
IDA: 通过直接分析推断
20080302 RGD
involved in negative regulation of blood pressure IMP
IMP: 通过突变表型推断
16507603 RGD
involved in negative regulation of cell population proliferation IMP
IMP: 通过突变表型推断
12177051 RGD
involved in positive regulation of cytosolic calcium ion concentration IMP
IMP: 通过突变表型推断
15576455 RGD
involved in response to xenobiotic stimulus IEP
IEP: 通过表达模式推断
18190998 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Bdkrb2 蛋白结构

7tmA_BK-2

7tmA_BK-2: cd15381 (65 - 349)

7tmA_BK-2

7tmA_BK-2: cd15381 (65 - 91)

7tmA_BK-2

7tmA_BK-2: cd15381 (98 - 123)

7tmA_BK-2

7tmA_BK-2: cd15381 (136 - 166)

7tmA_BK-2

7tmA_BK-2: cd15381 (179 - 200)

7tmA_BK-2

7tmA_BK-2: cd15381 (227 - 256)

7tmA_BK-2

7tmA_BK-2: cd15381 (269 - 299)

7tmA_BK-2

7tmA_BK-2: cd15381 (317 - 342)

  • 0
  • 100
  • 200
  • 300
  • 398 a.a.
蛋白主名 其他名称

B2 bradykinin receptor

B2R

BK-2 receptor

bradykinin receptor, beta 2

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS01457 BDKRB2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS01458 Bdkrb2 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS01459 Bdkrb2 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Bdkrb2 NCBI NCBI:624
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z