1. Gene
  2. Adk - adenosine kinase Gene

Adk - adenosine kinase Gene

中文名称:腺苷激酶

种属: Rattus norvegicus

同用名: AK

基因 ID: 25368 | 基因类型: protein coding

关于 Adk

Primary_assembly 15: 2,863,244-3,246,510 reverse strand.mRatBN7.2:CM026988.1

This gene has 2 transcripts (splice variants), 275 orthologues, 3 paralogues and is associated with 17 phenotypes. Biased expression in Liver (RPKM 121.9), Kidney (RPKM 595.5) and 9 other tissues.

功能概要

该基因编码的蛋白可启动腺苷激酶活性。参与多个过程,包括腺苷代谢过程;基因表达的昼夜节律调节;和 B 型胰腺细胞增殖。位于细胞质和细胞核中。用于研究脑梗塞。颞叶癫痫的生物标志物。该基因的人类直系同源物与由于腺苷激酶缺乏引起的高甲硫氨酸血症有关。与人 ADK(腺苷激酶)同源。 [由基因组资源联盟提供,2022 年 4 月]

Enables Adenosine Kinase activity. Involved in several processes, including adenosine metabolic process; circadian regulation of gene expression; and type B pancreatic cell proliferation. Located in cytoplasm and nucleus. Used to study brain infarction. Biomarker of temporal lobe epilepsy. Human ortholog(s) of this gene implicated in hypermethioninemia due to Adenosine Kinase deficiency. Orthologous to human ADK (Adenosine Kinase). [provided by Alliance of Genome Resources, Apr 2022]

Adk 基因产物(1)

mRNA Protein Name
NM_012895.3 NP_037027.2 adenosine kinase
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables adenosine kinase activity IDA
IDA: 通过直接分析推断
11833783 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in adenosine metabolic process IDA
IDA: 通过直接分析推断
12675911 RGD
involved in circadian regulation of gene expression IEP
IEP: 通过表达模式推断
12675911 RGD
involved in positive regulation of T cell proliferation IEP
IEP: 通过表达模式推断
16827901 RGD
involved in positive regulation of T cell proliferation IMP
IMP: 通过突变表型推断
16827901 RGD
involved in positive regulation of cardiac muscle hypertrophy IMP
IMP: 通过突变表型推断
21335462 RGD
involved in type B pancreatic cell proliferation IMP
IMP: 通过突变表型推断
22345561 RGD
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

Adk 蛋白结构

ribokinase_pfkB_like

ribokinase_pfkB_like: cl00192 (69 - 401)

  • 0
  • 100
  • 200
  • 300
  • 403 a.a.
蛋白主名 其他名称

adenosine kinase

adenosine 5'-phosphotransferase

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Adk NCBI NCBI:132